R&D Scientist
Scientist Job 18 miles from Pelham
Responsibilities Location(s) Woburn, Massachusetts Status Regular Job ID REQ-054897
Covaris, LLC (a PerkinElmer subsidiary) is a leading sample preparation solution provider in Biotechnology headquartered in Woburn, Massachusetts and has pioneered the Adaptive Focused Acoustics(AFA) technology platform, therebyrevolutionizing pre-analytical sample preparation in the world of Omics, such as genomics, proteomics, etc.
As a global leader in sample preparation technologies for life sciences research and molecular diagnostics applications, Covaris has successfully been awarded the ISO 13485 Quality System Certification. This certification demonstrates our commitment to meeting the highest international standards for medical device quality management systems and ensuring the high quality of life science research data for research and innovation.
Job Summary:
This position presents an exciting opportunity for a Scientist with life sciences education and experience. The candidate is expected to substantially contribute to Research and Development projects in a leading ISO13485 - certified biotech company. The successful candidate will be part of a multi-disciplinary R&D team that integrates the expertise and experience of biologists, chemists, physicists and mechanical and electrical engineers. The candidate will support research and development of next generation genome sequencing and protein analysis platforms, including reagents, consumables and instrumentation systems. This role requires interactions with multidisciplinary teams within and outside of The Company.
Essential Responsibilities and Position-related Expectations:
Planning, execution and analysis of experiments to prove feasibility of new ideas and concepts. Generating feasibility data reports and presenting data in meetings.
Writing protocols, executing experiments and perform data analysis. Presentation of results and conclusions in Reports and during Gate Review Meetings.
Interaction with engineering and manufacturing Teams for prototype testing and assistance in product development and design verification activities.
Migration of manually performed workflows to semi- and fully automated processes including the Company's Adaptive Focused Acoustics (AFA) instrumentation.
Ability to understand and to follow ISO13845 Operating Standards in all day-to-day activities.
Examples of day-to-day tasks include but are not limited to:
Feasibility experiments that may include
sample prep, i.e., isolation of biomolecules such as nucleic acids (DNA and RNA) and protein, downstream processing and analysis, with and without use of Covaris' proprietary AFAtechnology.
analysis of nucleic acids, such as quantification using various methods, including absorption, fluorescent quantification, qPCR and digital PCR mediated assessment of quantities and quality, electrophoretic molecular weight analysis, NGS library construction and sequencing runs on Illumina platforms.
analysis of proteins, including trypsin digests, ELISA assays and fluorescent quantification.
microbial and eukaryotic cell culture to develop novel sample prep workflows for manual as well as automated workflows.
Generation of Protocols, SOPs and work instructions.
Planning, directing and assisting V&V activities.
As a Successful Candidate You Will:
Be a self-starter, needing minimal daily supervision.
Be able to work towards given goals and deadlines.
Have excellent oral and written communication skills.
Have product development experience in a competitive environment.
Demonstrate solid analysis skills including Excel spreadsheet-based analysis and documentation, basic statistical knowledge.
Have experience in basic molecular biology techniques (PCR, electrophoresis, nucleic acid or protein isolation and purification).
Be knowledgeable about sterile cell cultures techniques.
Possess a strong team spirit and willingness to work in an interdisciplinary group of scientists and engineers.
Be flexible to perform, in addition to essential responsibilities listed above, other non-essential functions on an as-needed basis.
Be able to handle and process clinical specimens, such as whole blood, plasma, FFPE and fresh/frozen tissue, microbial cultures.
Qualifications:
Ph.D. or M.S. degree (MS with 2-3 years of experience) in biology, molecular biology, biochemistry, clinical diagnostics or a related life science field.
Experience in industrial/commercial settings is a plus.
Basic knowledge of document-controlled development processes is required.
Experience with NGS data analysis and NGS Technology in general is a plus.
PDN-9ea19232-c2d2-4aa8-bd87-addf789873ed
Staff Scientist, Computer Vision Algorithm Development
Scientist Job 31 miles from Pelham
We are seeking a highly skilled Staff Scientist, Algorithm Development to join our Computational Biology team. The ideal candidate will design, develop, and optimize computational methods to enhance 3D spatial transcriptomics analysis. In this role, you will leverage advanced statistical modeling and computer vision algorithms to improve data accuracy, scalability, and performance. Additionally, you will collaborate across teams to align technical solutions with research and product goals while effectively communicating complex insights.
Who we are:
Spun out of Stanford and MIT, Stellaromics is an innovative biotech startup founded in 2022 and located in Boston, MA. Our pioneering proprietary technology helps researchers and clinicians create comprehensive cellular maps enhancing our understanding of various diseases, with our flagship product STARmap and upcoming Pyxa™ suite of products. We have a passionate management team and committed investors who believe in our patented technology and overall mission to profoundly advance biomedical research and accelerate the discovery of life-saving treatments.
Responsibilities:
Lead the design, development and validation of computational methods-such as 3D image registration, spot detection, segmentation, and decoding-to improve the accuracy and efficiency of 3D spatial transcriptomics analysis for various tissue types.
Leverage advanced statistical modeling and data science techniques to interpret high-dimensional biological data.
Support integration of advanced algorithms into scalable, high-performance analysis pipelines.
Explore and apply cutting-edge frameworks (e.g., variational autoencoders, transformer architectures, and generative AI models such as denoising diffusion models) for improved data analysis and model performance.
Proactively ensure efficient execution by optimizing algorithms for parallel processing, including GPU acceleration where appropriate.
Collaborate effectively across teams to align technical solutions with product requirements and research objectives.
Communicate complex concepts and findings clearly and effectively, both verbally and in writing, to a variety of audiences, including customers.
Provide technical expertise in spatial transcriptomics and single-cell data analysis to inform strategic decision-making.
Qualifications:
Education and Experience
Ph.D. in Computational Biology, Bioinformatics, Computer Science, or a related field.
5+ years of relevant experience in image analysis, statistical modeling, genomics/transcriptomics, and machine learning, preferably in a fast-paced, product-driven environment.
Technical Skills
Demonstrated expertise in advanced statistical methods, including probabilistic modeling and unsupervised clustering.
Excellent command of Python and/or C++ for scientific computing and data analysis.
Experience with deep learning frameworks (PyTorch/ Tensorflow), high performance computing and large-scale data processing.
Knowledge of spatial modeling and analysis is a strong advantage.
Proficiency in GPU computing and experience designing algorithms optimized for parallel processing on GPU architectures is a plus.
Soft Skills
Excellent verbal and written communication skills, with the ability to document and manage data efficiently.
Product Development
Strong preference for candidates with practical experience in product development and a history of meeting project deadlines.
Additional Considerations
Submission of a GitHub profile link showcasing previous projects or contributions is encouraged.
Senior / Principal Scientist, Oligonucleotide Chemistry
Scientist Job 31 miles from Pelham
Senior/Principal Scientist, Oligonucleotide Chemistry - Permanent - Boston, MA
Proclinical is seeking a dedicated Senior/Principal Scientist in Oligonucleotide Chemistry to join a dynamic team focused on advancing therapeutic antisense oligonucleotides (ASOs and si RNAs). This role involves collaboration across various scientific disciplines to enhance the development targeted oligonucleotide therapeutics.
The Senior Scientist of Oligonucleotide Chemistry will:
Design, synthesize, and optimize ASOs and si RNAs for therapeutic applications
Evaluate and refine processes to improve synthesis yield, purity, and production timelines.
Contribute to the advancement of the oligonucleotide-based therapeutic pipeline.
Stay informed on emerging trends in oligonucleotide chemistry and contribute to intellectual property filings and publications.
Manage relationships with external contract research organizations to enhance synthesis capabilities.
Skills & Requirements:
Expertise in chemistry, biochemistry, or chemical engineering with a focus on therapeutic oligonucleotide discovery.
Hands-on experience with ASO and si RNA chemistry, including synthesis and modification.
Proven ability to design novel base pair modifications to enhance oligonucleotide properties.
Proficiency in analytical characterization techniques such as HPLC and LC-MS/MS.
Experience in establishing an oligonucleotide chemistry lab is advantageous.
Strong skills in managing contract research organizations.
Excellent analytical, research, and organizational abilities.
If you are having difficulty in applying or if you have any questions, please contact Max Robinson at m.robinson@proclinical.com
Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.
Proclinical Staffing is an equal opportunity employer.
INDSCIC
Sr. Battery Scientist
Scientist Job 24 miles from Pelham
Job Title: Senior Battery Scientist
The Senior Battery Scientist will be responsible for conducting in-depth research on advanced battery chemistries, focusing on the fundamental mechanisms and challenges associated with anode, cathode, and electrolyte materials. This role requires a strong theoretical and experimental background in electrochemistry and materials science. The ideal candidate will be a creative and innovative scientist with a passion for advancing battery technology.
Industry Background: Alsym Energy, Inc is a leading innovator in the rapidly changing field of battery energy storage. It is essential for the world to succeed in the transition to sustainable energy and batteries are at the very core of the solution. In fact, the IEA predicts that 60% of CO2 emission reductions in 2030 will be directly related to batteries. This mission is what drives us every day. Over the last few years, supply-chain constraints and significant safety incidents arising from lithium-ion batteries have reduced confidence in the suitability of the technology. We have developed a revolutionary new chemistry that enables the highest performing non lithium-ion battery in the industry, that is inherently non-flammable, non-toxic, and cost effective.
Responsibilities:
Chemistry Research:
Conduct fundamental research on the electrochemical behavior of high-energy battery materials.
Advanced electrochemical analysis, including cyclic voltammetry, electrochemical impedance spectroscopy, and galvanostatic cycling.
Pouch cell assembly and testing, including cycle testing, safety testing, and other performance characterizations (e.g., rate map, voltage stability window, etc.).
Investigate the reaction mechanisms and degradation pathways of anode, cathode, and electrolyte materials.
Develop, optimize, and implement characterization techniques and protocols to analyze battery materials and interfaces as a function of operational (e.g., state-of-charge) and environmental (e.g., temperature) parameters.
Design and implement test protocols to conduct ageing studies and predict long-term performance characteristics.
Collaborate with a cross-functional team to analyze the data.
Recommend design of novel electrode and electrolyte materials with improved performance and stability.
Collaboration & Communication:
Collaborate with cross-functional teams, including R&D, engineering, and manufacturing.
Mentor junior scientists and engineers.
Literature Review & Intellectual Property:
Stay abreast of the latest advancements in lithium-ion battery technology.
Conduct thorough literature reviews and identify research opportunities.
Contribute to the development of intellectual property.
Qualifications:
Education: Ph.D. in Chemistry, Materials Science, Chemical Engineering, or a related field.
Experience: 10+ years of experience in lithium-ion, sodium-ion or a related battery technology research in an industrial setting, including national laboratories.
Technical Skills:
Deep understanding of the fundamentals of battery chemistry.
Strong working knowledge of battery cyclers (Maccor, Arbin) and potentiostats (Biologic, Gamry).
Extensive experience with electrochemical analysis and material characterization techniques.
Proficiency in data analysis and interpretation.
Experience in battery modeling and simulation tools (e.g., COMSOL, ANSYS) will be a plus.
Soft Skills:
Strong analytical and problem-solving skills.
Excellent communication and presentation skills.
Ability to work independently and as part of a team.
Strong scientific curiosity.
Compensation, Benefits, and Perks:
We are committed to providing equitable compensation and a healthy working environment for our employees with a benefits package that provides the support that you need. We offer premium medical insurance cost through Blue Cross Blue Shield, dental insurance, offer a flexible Paid Time Off program, leave under PFML, and maintain a firm Anti-Harassment Policy. Every employee is also eligible for 401k, and stock options. A full listing of our benefits may be provided after an offer has been issued.
We are an equal opportunity employer at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, pregnancy, marital status, military or veteran status, or disability or any other status protected under state or federal law status.
Senior Research Scientist Explosion Protection
Scientist Job 37 miles from Pelham
FM is a leading property insurer of the world's largest businesses, providing more than one-third of FORTUNE 1000-size companies with engineering-based risk management and property insurance solutions. FM helps clients maintain continuity in their business operations by drawing upon state-of-the-art loss-prevention engineering and research; risk management skills and support services; tailored risk transfer capabilities; and superior financial strength. To do so, we rely on a dynamic, culturally diverse group of employees, working in more than 100 countries, in a variety of challenging roles.
The purpose of this position is to develop new scientific knowledge, engineering technologies, and innovative solutions to problems in explosion and blast protection, which can be used and applied by FM Global for mitigating industrial property loss. The primary responsibility of the position in FM Global is to plan, conduct, and communicate results of research projects in support of the critical business needs of FM Global.
The principal responsibilities are to carry out internally funded research projects in the areas of explosion and blast. Key areas of research include understanding of gas and dust explosion mechanisms through laboratory- and large-scale experiments as well as engineering and numerical modeling, and developing cost-effective protection solutions for explosion and blast hazards. The experimental, theoretical and numerical studies will be closely integrated with testing at various scales and the research work will be conducted by collaborating within the working team and internal and external stakeholders. Additional components consist of performing focused studies and conveying their results in a form suitable for use by FM Global engineers. Long-range studies of fundamental nature will be balanced with applied research focused on critical business needs.
The position is responsible for all aspects of project management including project proposal, execution, data analysis, budgeting, and documentation. In addition, the position is responsible for communicating and transferring research results for practical use within FM Global and, as appropriate, to outside organizations including the scientific/engineering communities and standard organizations. The position also acts as a consultant to FM Global business units as well as to insured clients.
The position requires a Ph.D. in Mechanical, Chemical, Aerospace Engineering, or related fields with a strong fundamental background in combustion, fluid mechanics, heat transfer, and applied mathematics.
Extensive experience in experimental methods in thermal fluids and combustion, and an understanding of associated numerical methods are required.
Excellent written and verbal communication skills, as well as demonstrated expertise in developing solutions to challenging technical problems, and a fundamental understanding of the physics relevant to explosion phenomena are required.
Title and salary are commensurate with qualifications and experience.
The final salary offer will vary based on geographic location, individual education, skills, and experience. The position is eligible to participate in FM Global's comprehensive Total Rewards program that includes an incentive plan, generous health and well-being programs, a 401(k) and pension plan, career development opportunities, tuition reimbursement, flexible work, time off allowances and much more.
FM Global is an Equal Opportunity Employer and is committed to attracting, developing, and retaining a diverse workforce.
#LI-TA1
Principal LLM Machine Learning Scientist
Scientist Job 31 miles from Pelham
Principal Machine Learning Scientist (Large Language Models)
DeepRec.ai seeks a dedicated Principal level Machine Learning Scientist specializing in Large Language Models, to join our client's innovative team in Cambridge, Massachusetts. This team are on a mission to transform mental health and well-being with AI.
Key Responsibilities:
Develop ML tools modeling psychological phenomena.
Run experiments on LLM-based multi-agent systems.
Use real-world data to fine-tune agent behavior.
Build an efficient data pipeline for product scalability.
Test techniques to enhance platform performance.
Collaborate with the team to improve KPIs and integrate the platform.
Present findings to diverse teams.
Qualifications:
PhD in ML, computer science, or related field.
Strong publications in deep learning and LLMs.
3+ years of industry experience.
Proficient in Python and ML libraries.
Team-oriented with excellent communication.
Leadership experience preferred.
Preferred: Background in cognitive psychology.
Please apply for more details, we look forward to hearing from you and sharing more details on this opportunity!
Process Development Associate
Scientist Job 16 miles from Pelham
Desired Education and Skills:
A.S. degree with 2+ years of lab experience. B.S. in a scientific discipline with 0-2 years of related experience preferred.
Hands-on experience or education in cell culture concepts, practices, procedures, and aseptic techniques.
Strong ability to apply basic engineering principles and statistical tools for troubleshooting and data analysis.
Experience in writing, revising, and following SOPs and MBRs preferred.
Ability to perform statistical calculations, weight and volume measurements as governed by SOPs and MBRs required.
Familiarity with common lab equipment and suppliesis required
Computer skills including Microsoft Excel, Word and Outlook
Strong organizational skills and attention to detail are necessary
Able to multitask and perform effectively under tight deadlines
Effective communication and listening skills are required
Ability to lift and carry up to 50 lbs.
Data Scientist, Computational Biology
Scientist Job 26 miles from Pelham
Data Scientist, Computational BiologyRepertoire Immune Medicines is a biotechnology company working to unlock and direct the remarkable power of the human immune system to treat cancer and autoimmune disease. The company was founded on the belief that understanding the repertoire of T cell receptor (TCR)-antigen immune synapses that maintain health and drive disease represents one of the greatest opportunities for innovation in medical science. Repertoire scientists created and developed the DECODE
TM
platform, which allows in-depth characterization of TCR-antigen pairs, and the ability to deploy this information in the form of novel targeted immune medicines to fundamentally reprogram the immune system to kill tumors or induce immune homeostasis.From its sites in Cambridge, Massachusetts and Zurich, Switzerland, Repertoire's team is advancing a pipeline of DECODE-enabled immune medicines. For cancer, we are developing a pipeline of TCR bispecifics molecules for treatment of multiple cancer types. In addition, we are developing a pipeline of mRNA tolerizing vaccines for treatment of autoimmune diseases.Repertoire was founded by Flagship Pioneering and is supported by a strong investor base. In addition, the company recently entered a strategic partnership with Bristol Myers Squibb to develop tolerizing vaccines for up to three autoimmune diseases. Role Overview Repertoire Immune Medicines is seeking a Data Scientist to join the Computational Science team to enable the discovery of new insights from our extensive and growing immune synapse database. The successful candidate will work at the interface of computational biology, data science, machine learning, and statistics with broad impact across early discovery, candidate development, and biomarker discovery. Key Responsibilities
Develop, evaluate, and implement rigorous analytical models and methods as needed for scientific discovery and development.
Assist in the conception, development, optimization, and assessment of machine-learning models for understanding the T-cell receptor-peptide-MHC interface.
Work alongside computer science engineers, wet-lab scientists, and project managers, contributing to early discovery, lead identification, lead optimization, and biomarker development.
Maintain familiarity with scientific literature to assist in the development and benchmarking of new methods.
Communicate findings both internally and externally via presentations and publication.
Qualifications/Experience
PhD in computational biology, machine learning, engineering, statistics, biostatistics, biomedical engineering, cancer biology, immunology, genetics or related field, or Master's with 3+ years experience, and a strong academic record.
Demonstrated impact in multi-disciplinary, team-driven scientific projects.
Expertise in programming in Python (including e.g. numpy, scipy, pandas, PyTorch, TensorFlow). Additional experience in R is helpful but not required.
Expertise in analyzing complex, high-dimensional datasets using scientific and computational best practices to make novel scientific discoveries.
Strong publication record.
Scientific curiosity and interest in working in a dynamic, rapidly developing field.
Background in immunology/immuno-oncology and experience working with single-cell sequencing data is a plus.
Repertoire is committed towards social responsibility and developing an inclusive culture. Much as the power of the immune system lies in the diversity of T and B cells, we believe that our work requires the creativity and ingenuity of a diverse workforce, and we are committed to pursuing that in all facets of the work experience at Repertoire. We will continue to educate ourselves about the inequities and barriers present in our society and act as a company where we can make a difference.
Repertoire is proud to be an Equal Opportunity Employer.
Recruitment & Staffing Agencies:
Repertoire Immune Medicines (“Repertoire”) does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Repertoire or its employees is strictly prohibited unless contacted directly by Repertoire's internal Human Resources team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Repertoire, and Repertoire will not owe any referral or other fees with respect thereto.
Data Scientist
Scientist Job 31 miles from Pelham
East Coast - Remote.
We are seeking a talented and driven Data Scientist to join our innovative team. As a leader in geospatial analytics and environmental monitoring, our organization leverages cutting-edge technology and advanced data science to unlock insights about the Earth's ecosystems. In this role, you will work on complex datasets, develop predictive models, and create solutions that empower clients to make informed decisions in addressing environmental challenges.
Key Responsibilities
Data Analysis and Modeling: Analyze large and complex geospatial datasets, including satellite imagery, remote sensing data, and environmental datasets, to extract actionable insights.
Algorithm Development: Design and implement machine learning and statistical algorithms to solve problems related to land use, carbon sequestration, biodiversity, and other ecological metrics.
Data Integration: Combine diverse data sources to create enriched datasets for analysis, including structured, unstructured, and spatial data.
Visualization and Reporting: Develop clear and impactful visualizations to communicate findings to both technical and non-technical stakeholders.
Collaboration: Work closely with software engineers, geospatial analysts, and domain experts to integrate data science solutions into our platform and products.
Innovation: Stay current with the latest advancements in data science, machine learning, and geospatial technology, and apply these techniques to improve our capabilities.
Data Quality and Ethics: Ensure high standards of data quality and promote ethical use of data in all analyses and models.
Qualifications
Required
Bachelor's or Master's degree in Data Science, Computer Science, Statistics, Environmental Science, or a related field.
Proficiency in programming languages such as Python, R, or JavaScript, with experience in data science libraries and frameworks (e.g., TensorFlow, PyTorch, scikit-learn).
Strong skills in geospatial tools and libraries (e.g., QGIS, GDAL, GeoPandas, or ArcGIS).
Solid understanding of statistical modeling, machine learning algorithms, and data preprocessing techniques.
Experience with cloud computing platforms such as AWS, Google Cloud, or Azure.
Proven ability to work with large datasets and databases (SQL and NoSQL).
Preferred
Knowledge of remote sensing technologies and image processing.
Experience with time-series analysis and predictive modeling in environmental contexts.
Familiarity with big data tools (e.g., Spark, Hadoop).
Strong communication skills with the ability to convey technical information to non-technical audiences.
Passion for environmental conservation and sustainability.
Post-doctoral Research Fellow
Scientist Job 31 miles from Pelham
in Orthopaedic Implant Research
Harris Orthopaedics Laboratory
The pioneering efforts of the Harris Orthopaedics Laboratory ********************** have positively impacted the quality of life of millions of patients through innovation and evidence-based medicine since its inception in 1969. The mission of the laboratory is to improve patient outcomes through materials science and clinical research with an emphasis on orthopaedic applications. Our is lab is a hub for scientists and engineers looking to make an impact in medicine.
Harris Orthopaedics Laboratory is focused on the development of polymeric and hybrid materials for applications in orthopaedics. Ebru Oral, Associate Professor of Orthopaedic Surgery ****************************************************************** is looking to hire a fulltime post-doctoral research fellow for a 3-4 year appointment. The laboratory is a focal point in the orthopedic research community for development of new materials and test methods for total joint replacements, which are implanted in over 2 million patients in the US alone each year. This is a great opportunity for scientists looking to apply their basic knowledge in translational research.
The development of antibacterial controlled release devices is a current focus for addressing periprosthetic joint infection. The laboratory is involved in the conception of materials, development of application processes, characterization for the appropriate clinical indication and the safety and efficacy testing in pre-clinical disease and surgery models.
The post-doctoral fellow will be responsible for:
The blending and compounding of polymeric blends of polyethylene
Polymer processing into solid forms including compression molding and extrusion
Post-processing such as radiation treatment or other cross-linking or sterilization methods
Physical, mechanical, tribological and chemical characterization of consolidated polymers
(Partly) Antibacterial efficacy testing of polymeric materials
Advanced Microscopy including Fluorescence imaging, Confocal imaging, Live imaging, and Electron microscopy (SEM/TEM)
Supervising biomedical research engineers in experimental work and presentation
Working with other team members and collaborators supporting delivery device formulation and preclinical studies for safety and efficacy.
Skills/Abilities/Qualifications
We are interested in interviewing experienced candidates with a strong background in polymeric materials. Candidates with experience in polymer processing and characterization are preferred. Familiarity with analytical chemistry and polymer synthesis methods is a plus.
Degree Requirements
Ph.D. in Polymer Science, Materials Science, Chemical Engineering, Mechanical Engineering, Pharmaceutical Science, Biomedical Engineering or other with appropriate experience.
How to Apply
Please submit your resume and cover letter to ********************* by April 15, 2025. We will review applications as we receive them. Anticipated start date: July 7, 2025.
Research And Development Technician
Scientist Job 6 miles from Pelham
Engineering Technician in R&D for a medical device client.
Troubleshoot and resolve issues that occur with products on the product lines.
Work with sales, marketing and R&D engineering to build prototype assemblies using internal resources and outside vendors.
Construct fixtures for the test and development of new and upgraded product.
Assist in the design of tests and perform feasibility testing of new product designs.
Write and/or contribute to ECOs for the implementation of designs and changes.
Specify and order parts & equipment in support of day-to-day functions.
Work cooperatively with Manufacturing Engineering to aid in the development and construction of new fixtures and to specify new equipment.
Microscope or magnification expertise a must.
Education/Experience:
AS plus minimum 3 years' experience in an engineering environment or equivalent
Medical device experience preferred
Ability to read and interpret mechanical and electrical drawings and BOMs.
Experience using basic meters, oscilloscopes, and hand tools
Bilingual English/Spanish preferred but not required
Ability to assemble and troubleshoot micro-assemblies under magnification
Must be able to work in a team environment
SolidWorks CAD experience a plus
Full time opportunity
Scientist
Scientist Job 26 miles from Pelham
Immunology R&D organization is expanding its early discovery team at the Cambridge Research Center (CRC) in Cambridge, MA. We are seeking a highly motivated contractor/Scientist III to join the Tissue Homeostasis team. Immune‐mediated inflammatory diseases (IMIDs) pose a high burden on the healthcare system worldwide. Long term remission from IMIDs represents an unmet need. Current therapeutic options that target the stromal compartments are limited, thus highlighting the urgent need to identify and validate novel stromal targets. At Tissue Homeostasis, we aim at deciphering the molecular mechanisms that perpetuate chronic inflammation across different tissues, with the ultimate goal to develop transformative therapeutics that can achieve IMID remission. In particular, we focus on understanding the stromal cell biology in the context of chronic inflammation and tissue damage/pathology. Key questions include but not limited to 1) how stromal cells communicate with immune cells to maintain homeostatic states of tissues; 2) how dysregulation of cell-cell and cell-extracellular matrix (ECM) interactions may contribute to inflammatory disorders; and 3) how key signaling aspects of tissue biology in health and IMIDs can be recapitulated in multi-cellular coculture systems or complex in vitro systems. As a contractor/Scientist III, the candidate will participate in target validation and assay development efforts with a focus on dissecting the molecular mechanisms underlying stromal inflammation. This is a hands-on and lab-based role requiring significant cell biology and immunology expertise, the ability to critically assess literature knowledge, and design experiments to support target validation and platform building processes in the Tissue Homeostasis team.
Key Responsibilities:
As member of the Tissue Homeostasis team, work with the company's Disease Discovery Teams (DDTs) and Genomics Research Center (GRC) team members to design and execute in vitro cell biology and mechanism of action experiments to advance target validation and assay platform development efforts in using immune cells and stromal cells.
Perform mammalian cell culture of primary and transformed cells.
Develop immune-stromal cell co-culture systems (e.g. Myeloid cells-fibroblast) to dissect signal transduction in cell-cell interactions with disease relevant cues
Perform qPCR analysis, flow cytometry, and Western Blotting analysis.
Perform cell-based assay with human primary cells and human cell lines (AlphaLISA, ELISA, HTRF, and proliferation assays).
Utilize technical knowledge and experience to effectively troubleshoot and optimize assays.
Maintaining laboratory notebooks to the required company standard.
Communicating results to internal meetings.
Interpret findings and effectively present scientific data, concepts, and recommendations to various internal audiences.
Compile and review technical reports, protocols, manuscripts, and other key documents.
Requirements:
Ability to work in a fast-paced environment and delivery results in a timely and agile manner.
Ability to work independently and collaboratively with cross-functional teams.
Willing to learn new techniques and develop new assays as needed
Extensive cell biology and immunology experience, proficiency in working with human primary cells and immortalized cell lines.
Experience with co-culture systems or complex in invitro systems with primary human cells
Demonstrated knowledge and experience of key cell biology assays and techniques.
Genetic manipulation of human cells using sh RNA/si RNA/CRISPR tools.
Proficiency in molecular biology skills such as qPCR analysis, flow cytometry, and Western Blotting analysis.
Trouble-shooter able to adapt ideas and experiments to achieve key project objectives and adhere to timelines.
Excellent communication of complex scientific ideas (written and verbal) and interpersonal skills.
Strong organizational skills required, in particular good time management skills.
Inclusive, open-minded, collaborative, and forward-thinking.
Desired:
Background in cell biology of inflammation or Immunology
Excellent oral and written communication, analytical, and computer skills.
Qualification:
Current or perspective BS/MS/PHD students in Biotechnology, Immunology, Molecular Biology, Cell Biology or Microbiology- 5 + years' experience
EEO:
“Mindlance is an Equal Opportunity Employer and does not discriminate in employment on the basis of - Minority/Gender/Disability/Religion/LGBTQI/Age/Veterans.”
Scientist II/III (Biologics CMC Developability Screening & Automation)
Scientist Job 41 miles from Pelham
Biologics Developability Screening and Automation-The Biologics CMC Developability team is an integral part of the Biologics CMC Drug Product Development organization. The Biologics CMC Developability team is responsible for- (1) the identification of biophysical- and chemical liabilities in discovery-stage biologic drug candidates to guide lead selection, and (2) for characterization of the key CMC attributes important for biologic drug development. We have an exciting opportunity for a motivated scientist to join the Biologics CMC Developability team based in Worcester, MA.
Responsibilities:
• Perform in-depth LC-MS based characterization of therapeutic biologic molecules and their post-translational modifications.
• Conduct biophysical and biochemical characterization of biologic drug candidates, as needed.
• Execute experimental protocols, collect results, and perform data analysis carefully and independently.
• Maintain excellent documentation of work including electronic lab notebook and protocols.
• Prepare and deliver concise scientific presentations of experimental results.
• Oversee maintenance of key laboratory equipment and routine laboratory operations.
• Build strong relationships with other team members and across groups.
• Understand and adhere to corporate standards regarding code of conduct, safety, and documentation compliance.
Skills:
• Hands-on experience with protein mass-spectrometry (subunit analysis, peptide mapping, disulfide mapping).
• Experience with biochemical and biophysical characterization of biologic proteins would be preferred.
• Experience with liquid handling robots and their programming would be highly beneficial.
• Demonstrated track record of independent thinking, creativity, and scientific accomplishment.
• Highly responsible and self-motivated. Skills to plan and conduct experiments with high quality and timely deliverables. Able to perform data analysis using MS Excel & GraphPad.
• Team player with collaboration and communication.
Education and experience:
• BS/MS in Biochemistry, Biology, Chemistry or equivalent, e.g., Chemical Engineering, Pharmaceutical Sciences with 5+ (BS) or 2+ (MS), or Ph.D. with 0+ years of biopharmaceutical industry experience.
• Candidates with less than 5 years/BS (3-5 years) will be considered for Scientist II.
About US Tech Solutions:
US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit ************************
US Tech Solutions is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
Recruiter Details:
Name: Shivangi
Email: *********************************
Internal Id: 25-36614
Process Development Scientist
Scientist Job 30 miles from Pelham
We are working with a growing Contract Development and Manufacturing Organization (CDMO) specializing in biologics development and manufacturing across both microbial and mammalian platforms.
We are seeking a highly motivated Scientist in Upstream Process Development, the ideal candidate will have a strong background in cell culture and Repligen ATF perfusion (or process intensification) with expertise in process development, optimization, and scale-up. This role will focus on designing and optimizing upstream processes to enhance biologics production efficiency and scalability.
Key Responsibilities
Develop and optimize upstream processes for biologics production using microbial and mammalian platforms.
Design and execute experiments to improve cell culture performance, including process intensification strategies.
Utilize Repligen ATF perfusion technology to enhance productivity and scalability.
Collaborate with cross-functional teams to ensure seamless technology transfer from development to manufacturing.
Analyze data, troubleshoot process challenges, and implement solutions to improve yield and efficiency.
Support scale-up activities from bench-scale to pilot and commercial production.
Maintain compliance with cGMP regulations and industry best practices.
Qualifications
PhD in Biotechnology, Biochemical Engineering, or related field.
1-2 years of hands-on experience in cell culture and process development.
Expertise in Repligen ATF perfusion technology or process intensification strategies.
Strong analytical and problem-solving skills with experience in process optimization.
Ability to work collaboratively in a fast-paced, innovative environment.
Please reach out to ************************** for more information.
BioTalent are acting as an employment agency in this hire.
Research And Development Scientist
Scientist Job 29 miles from Pelham
Qualifications:
Required Qualifications
• BS or MS in Chemistry or related discipline (No PhD)
Qualifications
• B.S. or Associate degree in a technical or scientific field with industrial lab experience with clean room + wafer level processing methods & tools.
• 1-2 years hands-on industrial experience in semiconductor fab or similar environment
• Familiarity with material characterization, wafer-level metrology and/or thin film analysis
• Highly motivated and effective at working both individually and within team environment to accomplish tasks and project goals
Responsibilities:
Key Responsibilities
• Associate investigator focusing on panel and wafer-level processing techniques, comfortable with exploring advanced/non-standard methods for unique applications
• Adept at hands-on lab work, creative thinking, problem solving in a unique and fast-paced laboratory environment
• Assume responsibility for execution of project workflows, such as laminations, coatings, lithography and cure techniques, as well as thermal and mechanical analysis.
• Key analytical techniques include CVS, HPLC, UPLC, GPC, % solids, titrations, potentiostatic measurements, surface tension, cloud point, densitometer, and rheometer.
• Proper documentation including new methods, method validation, batch data, management of change, etc.
• Support Research and Development of new additives and formulations used in electroplating and Polymeric / Dielectric products for the microelectronics industry.
• Help design and execute experiments, including operation of equipment and instrumentation for polymerization and electroplating of metals, electrochemistry, chromatography, optical microscopy, scanning electron microscopy, material, and mechanical testing, etc.
• Collect, analyze, and summarize data with appropriate documentation.
• Support Quality and Manufacturing for root cause investigations and customer complaints.
• Strict adherence to enhanced safety protocols and ability to work safely and participate in all group safety activities.
• Work safely in an R&D lab environment and hands-on experience needed.
Process Development Associate
Scientist Job 31 miles from Pelham
Job Responsibilities:
The Process Development Associate will be responsible for upstream process operations, including media preparation, bioreactor inoculation & monitoring
Responsible for maintaining strict adherence to cGMP guidelines and company SOPs, ensuring comprehensive documentation of all process operations.
You will participate in root cause analysis and continuous improvement initiatives to enhance process robustness and efficiency.
Provide training and mentorship to junior team members, fostering a culture of learning and professional growth.
Job Requirements:
Bachelor's degree in Biotechnology with at least 6 years of experience in upstream biologics manufacturing and development operations
Extensive experience working with bioreactors and automation systems, such as DeltaV or Cytiva Unicorn
You will need in depth experience working with cell culture techniques and fermentation processes.
Formulation Scientist
Scientist Job 29 miles from Pelham
Support Research and Development of new additives and formulations used in electroplating products for the electronics industry
Polymer synthesis and characterization
Help design and execute experiments involving equipment and instrumentation for electroplating of metals, electrochemistry, chromatography, microscopy, X-ray diffraction, material and mechanical testing, and additive synthesis.
Handle and mix plating bath components and additive solutions at both small and intermediate scales
Collect, analyze, and summarize data with appropriate documentation
Strict adherence to enhanced safety protocols and ability to work safely and participate in all group safety activities
Required Qualifications
Bachelor's degree in chemistry or related discipline
Demonstrated ability to handle wet chemistry and operate standard chemical and analytical instrumentation and equipment.
Highly motivated and effective at working both individually and within team environment to accomplish tasks and project goals
Preferred Requirements
Organic, inorganic, materials chemist
Experience with polymer synthesis
Experience with plating bath formulation, electrochemistry, or electrodeposition.
Experience with analytical techniques including X-ray Diffraction (XRD), cyclic voltammetry, and NMR.
Strong knowledge and demonstrated use of statistics and design of experiments (DOE) principles.
Thanks
Associate R&D Scientist
Scientist Job 18 miles from Pelham
Responsibilities Location(s) Woburn, Massachusetts Status Regular Job ID REQ-054996
This position presents an exciting opportunity for an Associate Scientist with life sciences education and experience. The candidate is expected to substantially contribute to Research and Development projects in a leading ISO13485 - certified biotech company. The successful candidate will be part of a multi-disciplinary R&D team that integrates the expertise and experience of biologists, chemists, physicists and mechanical and electrical engineers. The candidate will support research and development of next generation genome sequencing and protein analysis platforms, including reagents, consumables and instrumentation systems.
Essential Responsibilities and Position-related Expectations
* Planning, execution and analysis of experiments to prove feasibility of new ideas and concepts.
* Generation of highly reproducible data, data analysis and presentation of results and conclusions.
* Participation in prototype testing and assistance in product development and commercialization efforts.
* Migration of manually performed workflows to semi- and fully automated processes including the Company's Adaptive Focused-acoustics (AFA) instrumentation.
* Ability to understand and to follow Standard Operating Procedures to support day-to-day activities such as QC tests of instrumentation and reagents.
Examples of day-to-day tasks include but are not limited to:
* Sample prep, i.e., isolation of biomolecules such as nucleic acids (DNA and RNA) and protein, downstream processing and analysis, with and without use of Covaris' proprietary AFA technology.
* Analysis of nucleic acids, such as quantification using various methods, including absorption, fluorescent quantification, qPCR and digital PCR mediated assessment of quantities and quality, electrophoretic molecular weight analysis, NGS library construction and sequencing runs on Illumina platforms.
* Analysis of proteins, including trypsin digests, ELISA assays and fluorescent quantification.
* Microbial and eukaryotic cell culture to develop novel sample prep workflows for manual as well as automated workflows.
* Handling and processing of clinical specimens, such as whole blood, plasma, FFPE and fresh/frozen tissue, microbial cultures.
As a Successful Candidate You will:
* Be a self-starter, needing minimal daily supervision.
* Be able to work towards given goals and deadlines.
* Have excellent oral and written communication skills.
* Demonstrate solid analysis skills including Excel spreadsheet-based analysis and documentation, basic statistical knowledge.
* Have experience in basic molecular biology techniques (PCR, electrophoresis, nucleic acid or protein isolation and purification).
* Be knowledgeable about sterile cell cultures techniques.
* Possess a strong team spirit and willingness to work in an interdisciplinary group of scientists and engineers.
In addition to the essential responsibilities listed above, the employee may be required to perform other non-essential functions. Employees are required to follow any other job-related instructions and to perform any other job-related duties requested by their supervisor.
Qualifications:
* Master's degree with 2 years or bachelor's degree with 3+ years of experience in biology, molecular biology, biochemistry, or a related life science field.
Preferred Qualifications:
o Experience in industrial settings and/or basic knowledge of document-controlled development processes is a plus.
o Experience with NGS data analysis and NGS Technology in general is a plus.
PDN-9eb1aa02-b472-495d-9907-add8fbfede3c
Senior Research Scientist - Material Flammability, Fire Dynamics and Lithium-ion Battery Safety
Scientist Job 37 miles from Pelham
FM is a leading property insurer of the world's largest businesses, providing more than one-third of FORTUNE 1000-size companies with engineering-based risk management and property insurance solutions. FM helps clients maintain continuity in their business operations by drawing upon state-of-the-art loss-prevention engineering and research; risk management skills and support services; tailored risk transfer capabilities; and superior financial strength. To do so, we rely on a dynamic, culturally diverse group of employees, working in more than 100 countries, in a variety of challenging roles.
The purpose of this position is to develop new scientific knowledge, technologies and engineering solutions to problems in material flammability, fire dynamics and Lithium-ion battery safety research, which can be used for the prevention or control of industrial property loss.
The principal responsibilities are to carry out research projects in the areas of flammability, fire spread, and heat transfer in fires from solid combustible as well as Lithium-ion batteries. Key areas of research include understanding of fire behavior at the medium and large scales via bench-scale experiments and theoretical models on material flammability and flame heat transfer. Projects can also involve advanced flame diagnostic of buoyant turbulent sooty flames and wall fires. The experimental and theoretical studies will be closely integrated with Computational Fluid Dynamic (CFD) model development and validation within the work group.
The position is responsible for all aspects of project management including project proposals, execution, and reporting.
The position requires a PhD in Mechanical, Chemical Engineering, Fire Protection Engineering, or related fields with a strong fundamental background in combustion, fluid mechanics, heat transfer, material science and applied mathematics. Extensive experience in experimental methods in thermal fluids, material flammability, heat transfer, combustion/fire, and an understanding of associated numerical methods are required. Research experience with advanced laser diagnostics in flame, experimental measurement in turbulent flame, heat transfer and failure analysis of battery is desirable. Also needed are excellent written and verbal communication skills, as well as demonstrated expertise in developing solutions to challenging technical problems.
The final salary offer will vary based on geographic location, individual education, skills, and experience. The position is eligible to participate in FM's comprehensive Total Rewards program that includes an incentive plan, generous health and well-being programs, a 401(k) and pension plan, career development opportunities, tuition reimbursement, flexible work, time off allowances and much more.
FM is an Equal Opportunity Employer and is committed to attracting, developing, and retaining a diverse workforce.
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Scientist II (Human Blood Cell Isolation & Characterization)
Scientist Job 41 miles from Pelham
• Isolation & characterization of human blood cells.
• Contractor will request donor samples, isolate cells from human or monkey peripheral blood, set up cultures with isolated cells, perform cell stimulation or differentiation by test compounds, harvest cells and supernatants, prepare these samples for further analysis; run ELISA tests to study effector function of compounds; analyze and present the data generated by these experiments.
Top skill requirements:
• Primary cell isolation and culture.
• ELISA.
• Flow cytometry highly preferred.
• Basic lab techniques, pipetting samples, dealing with cells, cleanliness.
• Enthusiastic.
Education and experience:
• BS or MS & 3-5 years of biochemistry lab experience.
Work environment:
• 100 % Lab, benchwork.
About US Tech Solutions:
US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit ************************
US Tech Solutions is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
Recruiter Details:
Name: Shivangi
Email: *********************************
Internal Id: 25-35946