Scientist Jobs in Monrovia, CA

Clear Skies is incubating a stealth venture that uses an AI-powered platform to serve major stakeholders in private equity. We operate at the intersection of finance/AI to optimize deal flow, automate decisioning, and integrate networks into a seamless customer journey. Our team is composed of seasoned professionals from private equity, financial advisory, human capital, and AI engineering. We are seeking a Founding Head of AI Products to spearhead the development of AI-driven solutions that redefine how investments are sourced, evaluated, and executed. You will define the product and lead AI initiatives to solve real-world problems in a multi-billion-dollar industry. Key Responsibilities: Product Strategy Execute AI product strategies for market fit and business impact. Analyze customer needs and competitive landscape to uncover new product opportunities. Build business cases with market analysis, ROI projections, and scalability assessments. AI Product Development Define features and workflows to gather customer feedback and iterate on MVP development. Build AI-powered engines to transform large-scale unstructured data into actionable intelligence. Implement NLP techniques for semantic search and keyword matching from unstructured data. Utilize embedding models for vector-based search and context understanding. Workflow Automation Establish scalable AWS-based infrastructure and data pipelines. Develop automated communications, scheduling, and self-service AI tools. Implement best practices for AI model versioning, monitoring, and optimization. Leadership & Collaboration Lead and mentor AI and product teams, promoting innovation and learning. Collaborate with business leaders to align AI strategies with goals. Define and track KPIs to measure product success and guide development. Key Qualifications: 10+ years in product leadership with focus on AI/ML platforms and generative AI technologies. Expertise in AI/ML frameworks (TensorFlow, PyTorch, etc.) and cloud infrastructure. Experience in financial services or private equity is a plus. Application Process: Interested candidates are invited to submit their CV and cover letter detailing relevant experience and qualifications to ***************************. About Clear Skies: Clear Skies is a private equity investment firm that acquires middle-market businesses. We partner with management teams to drive growth and value through our global networks.

Job Title: Research Scientist II, DMPK Annual Base Salary: DOE, $128,000-$175,000 along with bonus eligibility and a comprehensive benefits package Our Mission The Ellison Medical Institute, formerly known as the Ellison Institute of Technology Los Angeles, strives to spark innovation, leverage technology, and drive interdisciplinary, patient-centered research to continually enhance health, reimagine and redefine cancer care, and transform lives. Established in 2016 as a medical research and development center, the Institute features innovation labs for artificial intelligence and molecular analytics and was among the first organizations to vertically integrate the interdisciplinary study and treatment of disease. We offer multifaceted programs, including a preventative medicine and cancer clinic, cross-disciplinary research laboratories, a health policy think-tank, and community outreach and educational programs. Please visit emila.org for more details. Job Summary The Ellison Medical Institute is seeking an accomplished and passionate Research Scientist in Drug Metabolism and Pharmacokinetics (DMPK) to join our Translational Biology team. In this high-impact role, you will apply your expertise in pharmacokinetics (PK), toxicology (TOX), and drug metabolism (ADME) to accelerate the advancement of groundbreaking new molecular entities. Your work will directly contribute to optimizing drug properties and ensuring that our innovative drug candidates are ready for clinical trials. As a subject matter expert, you'll design and lead PK/TOX studies, working closely with both internal teams and Contract Research Organizations (CROs) to ensure rigorous compliance with regulatory standards and IND-enabling requirements. Collaborating with early-stage and preclinical development teams, you'll drive innovative approaches, incorporating new technologies and methodologies to expand our drug discovery pipeline. This is a unique opportunity to be at the forefront of early-stage drug development, in a collaborative, multidisciplinary environment, where your contributions will help shape the future of medicine. Why You Should Join Us: Drive Innovation: Contribute to the advancement of cutting-edge drug development and therapeutic strategies that transform patient care. Be at the Forefront: Work with a world-class team and integrate new technologies in PK/TOX and ADME studies to accelerate the drug discovery pipeline. Make an Impact: Help shape clinical trial strategies and regulatory pathways that will support the successful progression of therapeutic candidates into clinical trials. Job Accountabilities: Lead PK/TOX and ADME Studies: Design and manage PK, TOX, and ADME studies to optimize drug properties and prepare for regulatory submission. Oversee study execution both internally and through CROs. Data Analysis and Modeling: Analyze and interpret PK/TOX and ADME data using industry-standard tools, including human PK predictions and clinical translation, to inform drug development decisions. CRO Management and Oversight: Build strong relationships with external CROs, ensuring study quality, compliance with regulatory standards, and alignment with IND-enabling requirements. Cross-Functional Collaboration: Collaborate closely with clinical, engineering, and biochemistry teams to provide guidance on PK/TOX strategies and data interpretation, enhancing overall drug discovery efforts. Innovation and Technology Integration: Work with early and preclinical development teams to integrate cutting-edge technologies and methodologies, driving the innovation of PK and toxicology assessments to expand the drug discovery pipeline. ADDITIONAL INFORMATION Required Education & Experience: PhD in Pharmacokinetics, Toxicology, Drug Metabolism, Pharmaceutical Sciences, Pharmacology, or a related field, with 2+ years of relevant industry experience; or MS in the same fields with 5+ years of industry experience in DMPK, pharmacology, or toxicology. Proven track record of designing and interpreting PK/TOX and ADME studies to support drug discovery and development. Expertise in analyzing and modeling PK, TOX, and ADME data, including human PK predictions and clinical translation, using industry-standard software tools. Experience managing CROs conducting PK/TOX studies, ensuring quality, compliance, and alignment with IND-enabling requirements. Experience working across multiple drug modalities, including small molecules and biologics, is preferred. For the safety and health of employees, guests, and patients, the Ellison Medical Institute may mandate vaccination requirements for employment. The Ellison Medical Institute's policies are always subject to review and change to ensure they are appropriate under the circumstances. The Ellison Medical Institute is an equal opportunity employer. We believe that an inclusive, collaborative team environment is just as important to our mission as stethoscopes and microscopes. We strive to always provide employees a supportive atmosphere, so they feel confident taking creative risks toward innovation. The Ellison Medical Institute values emotional intelligence and communication with empathy and respect for others. We seek to build a diverse group of people who are curious, have a deep sense of responsibility, and the grit needed to achieve excellence.

Are you an authority in clinical drug development, possessing the capabilities to drive a successful strategy in accelerating the development of cellular therapies for patients with immune-mediated diseases? Are you dedicated to revolutionizing the treatment of immune-mediated diseases and crafting a significant impact on patients' lives? Do you have a passion for science and clinical development experience in Immunology and CAR-T cell therapies? Do you possess both strategic and operational leadership skills? If so, we invite you to join us! We are currently seeking a Global Development Scientist Director to be based in Boston Seaport. About AstraZeneca AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. We are more than one of the world's leading pharmaceutical companies. Immunology Cell Therapy Our ambition is to build a premier organization that accelerates the delivery of ground-breaking cell therapies for patients with immune mediated diseases. It's our vision that unites and encourages us. Cell therapies represent a fundamental evolution of how drugs are discovered, developed and manufactured. These new advanced potentially curative cellular modalities require a development strategy to ensure their rapid availability to patients. With multiple autoimmune and inflammatory indications and clinical stage cell therapies in global development, we actively move forward. Focus on pioneering science with the latest technology to achieve breakthroughs. AZ is a place built on courage, curiosity and collaboration - we make ambitious decisions driven by patient outcomes. Responsibilities The Global Development Scientist Director will provide scientific and clinical input to all aspects of early-stage product development. This includes but is not limited to the design, delivery and interpretation of pivotal clinical trials and of studies that further characterize the overall benefit and risk and value of products in respiratory and immunology therapeutic area (TA) in early-stage development. In this role, the scientist will seek input from the appropriate functional authorities and will coordinate these activities in support of clinical studies and programs. The Global Development Scientist Director ensures that the safety evaluation process for early-stage phase I trials is seamless and complete. The objectives of the Global Development Scientist Director will be set by the Global Clinical Product Lead in agreement with Global Clinical Head(s). The role will have a special focus on early-stage clinical trials within the respiratory and immunology TA where the Global Development Scientist Director will work in close collaboration with the study team physician and other collaborators with all aspects of scientific input, clinical data quality metrics and safety evaluation. You will be expected to effectively collaborate with colleagues in the early stage respiratory and immunology development and early development groups. Other capabilities are to demonstrate clear and professional verbal and written communication, presenting scientific results to multidisciplinary teams and key collaborators. Work as a member of a diverse and motivated team of scientists spanning across multiple divisions of Biopharmaceuticals R&D. The Global Development Scientist Director will lead independently some activities and contribute to regulatory submissions, process improvement, and mentoring. Accountabilities Provide scientific leadership in the design, execution, and interpretation of clinical trials in one or more development programs. Effectively collaborate with colleagues in other functions including Patient Safety, Regulatory Affairs, and Clinical Operations, and early development groups. Be involved primarily in early stage (Ph1) clinical programs collaborate with clinical colleagues as well as medical affairs colleagues. Provide experienced scientific input into the preparation of regulatory documents and interactions with regulatory authorities. Provide expert scientific analysis and interpretation of data from studies and in the literature. Lead development of quality metrics and data review plan for assigned studies. Support and contribute to medical monitoring of trials. Lead and participate in activities that ensure quality, consistency and integration of clinical study related deliverables and ensure safety evaluation process within the clinical team. Ensure scientific input to TA standards. Provide scientific evidence to support strategic decision making for R&D, marketing, clinical, and business development departments. Present protocol and scientific results to multidisciplinary teams and key collaborators. Develop and review protocols, informed consent, investigator's brochure, and other clinical development documents. Organize and analyse data from clinical research to build new hypothesis. Required Skills/Experience Scientific doctoral level degree (e.g. PhD or PharmD), relevant equivalent clinical qualification, with extensive experience from clinical development. Five or more years of relevant pharmaceutical experience (multi-country clinical trials) is required. Understanding of scientific and clinical issues related to the design and implementation of clinical trials and interpreting trial results particularly in respiratory and immunology clinical development. Ability to work collaboratively in a cross-functional setting. Experience particularly in Phase I and Phase II clinical development. Desired Skills/Experience Experience with regulatory submissions, life cycle management, advisory boards, annual safety updates. When we put unexpected teams in the same room, we fuel ambitious thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our outstanding and daring world. Why AstraZeneca? At AstraZeneca, we are driven by 'following the science'. We are a science-driven organization where innovation is backed by investment and ambitious decision-making. Here, your discoveries will ultimately have the potential to reach billions of patients in need, all across the globe. We are a team of leading specialists, driven to pursue scientific knowledge. We see the bigger picture and know where we can make the biggest impact. We are never complacent about scientific discovery and development. Here we are always pushing our efficiency, searching for new knowledge and the next breakthrough. Ready to make a greater impact? Apply now! #J-18808-Ljbffr

About Us: We are a pioneering liquid biopsy company dedicated to advancing non-invasive diagnostic technologies. Our mission is to enable early disease detection and monitoring through cutting-edge molecular biology techniques. We are seeking a motivated Scientist to join our dynamic team and contribute to our innovative solutions in liquid biopsy. Job Summary: The ideal candidate will be an experienced molecular biologist with a strong background in qPCR, nucleic acid extraction (DNA/RNA), cell culture, and data analysis. Additionally, experience working with liquid handlers, preferably Star Hamilton, is highly desirable. You will play a key role in developing and optimizing assays, analyzing datasets, and contributing to the research and development of our core technologies. Key Responsibilities: Assay Development: Design, optimize, and validate qPCR assays for liquid biopsy applications. Nucleic Acid Extraction: Perform and improve workflows for high-yield, high-quality DNA and RNA extraction from various biological samples (e.g., blood, plasma, cells). Cell Culture: Maintain and manipulate cell cultures for experimental models. Data Analysis: Analyze and interpret qPCR and other molecular biology data using statistical tools. Liquid Handlers: Develop, optimize, and execute workflows using liquid handling systems, preferably Star Hamilton. Collaboration: Work closely with cross-functional teams, including Quality, Manufacturing, and documentation teams, to drive projects forward. Documentation: Maintain detailed experimental records and contribute to regulatory documents and reports. Presentation: Communicate findings to internal teams. Qualifications: Education: PhD in Molecular Biology, Biochemistry, Biotechnology, or a related field with 2-5 years of relevant experience or Bachelors/Master's degree with 5-8 years of industry experience. Technical Expertise: Hands-on experience with qPCR assay development and troubleshooting. Proficiency in DNA/RNA extraction techniques and handling of liquid biopsy samples. Expertise in cell culture, including primary and immortalized cell lines. Knowledge of working with liquid handlers, preferably Star Hamilton.

Sr. Research Scientist or Research Scientist- Protein Chemistry Kelly Science & Clinical is seeking a (Sr.) Research Scientist for a full-time, on-site, direct hire position at Biotech company in Irvine, CA. If you're passionate about bringing the latest scientific discoveries to life and are ready to take the next step in your career, trust The Experts at Hiring Experts. Overview We are seeking a (Sr.) Research Scientist to lead R&D efforts in developing reagents and assays to support new biomarker and IVD capabilities. This role will focus on allergen characterization, extraction, purification, and conjugation, as well as the development of allergy-specific IgE, IgG4, and autoimmunity IgG assays (ANA, RF, ds DNA, vasculitis, neuro disorders). The ideal candidate will have expertise in protein stability, SDS-PAGE, Western blot, Abby, and FPLC, with a strong background in protein characterization and assay development. Key Responsibilities Develop reagents for new biomarker and IVD assays, including allergens and autoimmunity assays. Design and execute experiments, analyze data, and interpret results using statistical tools. Lead cross-functional teams to ensure research aligns with product development goals. Collaborate with suppliers to synthesize and characterize custom reagents. Troubleshoot technical challenges and ensure work complies with relevant standards. Oversee the transfer of reagents from R&D to manufacturing with appropriate QC procedures. Mentor research associates and contribute to the training of team members. Qualifications Ph.D. or MS in Chemical Engineering, Biochemistry, Bioengineering, or a related field. 1-3 years of experience in IVD R&D for PhD; 8+ years for MS. Experience with allergen extraction, purification, and conjugation, as well as allergy-specific and autoimmunity IgG assays. Proficient in protein characterization (SDS-PAGE, Western blot, HPLC, FPLC) and purification techniques (IEX, SEC, affinity chromatography). Experience with immunoassay techniques is a plus. Strong background in experimental design, data analysis, and troubleshooting. Excellent communication and collaboration skills. Preferred Skills Bio-conjugation experience, particularly with proteins, peptides, and nucleic acids. Experience developing life science reagents and working in an aseptic lab environment. What Happens Next: Once you apply, our team will review your qualifications. If your skills align with the role, we'll contact you for the next steps in the interview process. Even if this position isn't the perfect fit, joining our network opens the door to future opportunities. We look forward to reviewing your application!

Summary: The R&D Formulator develops and optimizes formulations, conducts testing, and ensures accurate documentation. Supports technology transfer, collaborates cross-functionally, and stays updated on industry trends. Maintains lab safety, mentors staff and participates in management meetings. Evaluates raw materials, improves formulations, and oversees special projects as assigned. Essential Duties and Responsibilities Formulation creation (bench mix, formulation sheet, product description sheet, sample measurement, color verification, etc.) Writes and/or reviews procedures, purchase orders, quotes, and specifications needed to support product development activities Develops and/or performs all formulation requirements on new formulas Documents test results, specifications, and final formula procedures in a standard format for inclusion in the master file Participates in the technology transfer from pilot scale to manufacturing Communicates, in a timely fashion, all information regarding formulation, project status, raw material research, results, etc. to all appropriate individuals in Purchasing, Sales, Customer Services, and Quality departments Conducts intellectual searches for technical information through a variety of resources Keeps abreast of current trends, practices, developments, and regulatory changes, which would impact products, procedures, or formulation Ensures the maintenance and/or adherence to good laboratory practices and all safety regulations both in laboratory and manufacturing areas Provides technical knowledge in guiding other assistants/technicians in the R&D Lab Develops and presents to the R&D Manager or Director, R&D matters requiring his/her decision Participates in scheduled Management and Sales meetings in the absence of the R&D Manager/Director Evaluate new and alternative raw materials for functionality and stability Assist in verification studies as required Reformulate to improve existing products as needed Special projects as needed and any other tasks assigned by the R&D Director or Manager. Qualifications/Education/Experience: Minimum Bachelor of Science in Chemistry or related field 2+ years' Experience in R&D, Quality Assurance, Quality Control or Manufacturing is required; nutritional, pharmaceutical or biotechnology experience preferred; Have strong eye for color, finish, and detail Must have proficient math skills; weights and volumes experience a plus Excellent communications (verbal/written) Excellent organizational and multi-tasking skills Proficient with MS Word, Excel, Teams, and Outlook Work Environment: The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. While performing the duties of this job, the employee is occasionally exposed to work near moving mechanical parts, fumes, or airborne particles and risk of electrical shock. The noise level in the work environment is usually moderate. Physical Demands: The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. Physical demands require sitting for extended periods of time, walking, bending, reaching, carrying, and occasionally lifting and/or moving objects up to 25 pounds. Specific vision abilities required by this job include Close vision, Peripheral vision, and the ability to adjust focus. While performing the duties of this job, the employee is occasionally required to use hands to finger, handle, or feel; reach with hands and arms; climb or balance; stoop, kneel, crouch, or crawl and talk or hear.

***This is an ONSITE position reporting to client's USTO Thousand Oaks location 100%. Local Candidate Only*** EW will be working 8 AM - 5 PM PT, will need an EW who can support client core hours. This will be an office based role, utilized for quality control of the instruments the Scientists are using. We are looking for a candidate with skills to support the quality control/review of nonclinical scientific reports. Role Responsibilities Knowledge of regulatory (GMP, GLP and GCP) and pharmaceutical processes is recommended. Confirm the accuracy of experimental data contained in written reports against final summary analysis files and ELN, e.g., QC of text, tables and figures. Confirm that experimental data used in reports to support conclusions accurately reflect ELN data sources (traceability to various internal data repositories or systems or source data verification) Coordinate, organize and support the QC process by accessing multiple internal databases (e.g., ELN, CDOCs, RIM, LIMS, etc.) to complete the QC task.

Are you excited by the potential of large-scale carbon removal? If so, Captura Corp. is seeking a Senior Scientist in Ocean Modeling to join us. Captura is an early-stage technology start-up with the mission to develop globally scalable carbon removal to support a sustainable future for the world's climate. Captura's unique technology was developed and proven in Caltech's laboratories and uses established electrochemical concepts to enable gigaton-scalable solutions for removing carbon dioxide (CO2) from the atmosphere via direct ocean capture. We capture carbon dioxide using only renewable electricity and seawater, creating no byproducts. CO2-depleted seawater is returned to the ocean to absorb CO2 that comes from the atmosphere. As Senior Scientist in Ocean Modeling, you will work closely with Captura's Principal Oceanographer and the MRV team. This role is critical in the validation of Captura's technology. Key Responsibilities: Lead Captura's modeling initiatives with a strong focus on fluid dynamics and transport in coastal and open-ocean systems. Employ regional ocean biogeochemical models to quantify atmospheric CO₂ drawdown and evaluate ecosystem impacts. Develop and implement near-field fluid dynamics modeling techniques to track and predict plume behavior. Validate models through comparison with in situ monitoring data, ensuring accuracy and reliability. Create and refine modeling tools to support deployment site selection and the design of monitoring plans for future projects. Collaborate with the marine carbon dioxide removal MRV modeling community to share insights, best practices, and integrate new methodologies. Partner with internal MRV teams to align modeling efforts with project goals, timelines, and broader organizational objectives. Educational/Experience Requirements: PhD in Physical or Chemical Oceanography or a closely related discipline. 5+ years of experience utilizing the Regional Ocean Modeling System (ROMS) or similar ocean modeling frameworks. Deep expertise in fluid dynamics, seawater carbonate chemistry, and coastal ocean processes. Demonstrated proficiency in Python, Julia, or other relevant programming languages. Strong analytical and problem-solving skills, with a proven track record of taking initiative and thriving in a collaborative team environment. Excellent communication skills, both written and verbal, to convey complex modeling results to diverse audiences. A passion for innovation and commitment to advancing carbon removal technology at scale.

Metric Bio has partnered with a company focused on large-scale carbon removal technologies. This pioneering venture seeks a Senior Scientist in Ocean Modeling to harness electrochemical concepts and proven innovations from top academic research for global, gigaton-scalable carbon dioxide (CO2) removal solutions through direct ocean capture. Using only renewable electricity and seawater, the technology involves no byproducts, and CO2-depleted seawater is returned to the ocean, promoting further atmospheric CO2 absorption. As the Senior Scientist in Ocean Modeling, you will collaborate closely with the Principal Oceanographer and the Monitoring, Reporting, and Verification (MRV) team to validate this breakthrough technology. Key Responsibilities: Lead the company's modeling initiatives, focusing on fluid dynamics and transport in coastal and open-ocean systems. Utilize regional ocean biogeochemical models to assess atmospheric CO2 drawdown and its impacts on ecosystems. Develop and apply near-field fluid dynamics modeling techniques to monitor and forecast plume behavior. Ensure model accuracy and reliability by comparing them against in situ monitoring data. Enhance modeling tools to aid in selecting deployment sites and designing monitoring plans for future expansions. Engage with the marine carbon dioxide removal MRV modeling community to exchange knowledge, share best practices, and incorporate new methods. Work alongside internal MRV teams to ensure modeling efforts align with project goals and organizational objectives. Requirements: PhD in Physical or Chemical Oceanography, or a closely related field. Over 5 years of experience with the Regional Ocean Modeling System (ROMS) or similar frameworks. Expertise in fluid dynamics, seawater carbonate chemistry, and coastal ocean processes. Proficiency in programming languages such as Python or Julia. Strong analytical and problem-solving abilities, with a history of proactive initiative in team settings. Excellent communication skills to articulate complex modeling outcomes to a variety of audiences. A dedicated innovator with a commitment to advancing scalable carbon removal technologies.

Join Amgen's Mission of Serving Patients At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission to serve patients living with serious illnesses drives all that we do. Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas: Oncology, Inflammation, General Medicine, and Rare Disease, we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives. Our award-winning culture is collaborative, innovative, and science-based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Principal ScientistWhat you will do Let's do this. Let's change the world. We are seeking a highly motivated Principal Scientist to join the Structural Biology group at our site in Thousand Oaks, CA. The Structural Biology group provides comprehensive molecular insights and structure-based design for drug-target assessment, mechanism of action, protein-protein and protein-ligand interactions, as well as protein engineering to facilitate drug discovery across various therapeutic areas. The Principal Scientist will be responsible for structure determination of target molecules using X-ray crystallography and cryo-electron microscopy (cryo-EM). Interact directly with small molecule scientists including computational scientists, medicinal chemists, and protein engineers. Apply knowledge to new areas of study, with strong interpersonal and communication skills to thrive in a highly collaborative environment. What we expect of you We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a leader with these qualifications. Basic Qualifications: Ph.D. with a deep understanding of structural biology and general biochemistry and biophysics. Significant postdoctoral AND industrial (pharma/biotech) research experience, in large macromolecular complex structure determination. Knowledge of state-of-the-art protein structural biology techniques including all aspects of construct design, expression, purification, characterization, structure determination, and analysis. Proven expertise on protein crystallography AND cryo-EM single particle analysis, to determine atomic resolution structures. Experience with ubiquitin-proteasome system for protein degradation is a plus. Excellent presentation skills (written and oral) for effective team-based communication of results. Ability to work independently and effectively within timelines and to collaborate in a multidisciplinary environment. Willingness to take on new/unfamiliar responsibilities to help the team. Skills in managing multiple projects and capability to prioritize. Preferred Qualifications: Experience with other protein biochemical and/or biophysical characterization of protein complexes. What you can expect of us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan. Stock-based long-term incentives. Award-winning time-off plans. Flexible work models, including remote and hybrid work arrangements, where possible. Apply now for a career that defies imagination. Objects in your future are closer than they appear. Join us. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. #J-18808-Ljbffr

Apply remote type On Site locations US - California - Thousand Oaks time type Full time posted on Posted 2 Days Ago job requisition id R-203821 Career Category Research Job DescriptionJoin Amgen's Mission of Serving Patients At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do. Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives. Our award-winning culture is collaborative, innovative, and science-based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. What you will do We are building upon our solid Cardiovascular foundation and long-term dedication to patients by developing a whole new class of novel molecules. We are seeking a dedicated and highly motivated Principal Scientist to become a member of the Department of Cardiometabolic Disorders within Amgen Research located in Thousand Oaks, CA. In this vital and exciting role you will be an ideator and drug hunter and are expected to conduct biology research and identify therapeutic targets in cardiometabolic disease that are tractable and offer the opportunity of delivering disease-modifying potential in patients. The proposal and advancement of a drug discovery program will be based on a sound and compelling scientific rationale that may include validation from human genetics and/or clinical studies. Critical thinking, ingenuity, the ability to design and conduct mechanistic studies and deep biology, technical proficiency, excellent communication skills, integrity and the ability to work in a multi-disciplinary environment will be critical toward advancing programs in the cardiometabolic pipeline. You will initially work at the bench conducting in vivo and/or in vitro preclinical studies with a focus on PAH, vascular disease and/or heart failure. Over time, you will also demonstrate strong leadership skills and the ability to manage a team of scientists conducting drug discovery research. As part of the team, the candidate may also support other new and existing drug discovery programs in the department to help advance the best assets in the Cardiometabolic Disorders portfolio. Conceptualizing and proposing therapeutic targets for the treatment of cardiometabolic disease Designing and performing in vitro and cell-based experiments Independently performing data analysis and interpreting results Communicating scientific results through written and oral presentations Collaborating with teams from other functions in the company to advance our programs Documenting work through written protocols, electronic laboratory notebooks and study reports. Advising colleagues in areas of expertise What we expect of you We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a scientist with these qualifications. Basic Qualifications: Doctorate degree and 2 years of scientific experience Or Master's degree and 5 years of scientific experience Or Bachelor's degree and 7 years of scientific experience Preferred Qualifications: PhD with postdoctoral experience in cardiometabolic disease (industry experience is strongly preferred) Strong target ideation capabilities and critical thinking to enable discovery of innovative medicines for patients Exceptional in vivo and/or in vitro pharmacology skills and capability to independently design, implement and analyze studies with proper controls and generate reproducible high-quality data Technical mastery of general molecular biology, biochemical, and cell-signaling techniques including immunoblotting, immunocytochemistry, RT-qPCR, immunoprecipitation, and ELISA Basic knowledge of statistical methods applied in a consistent and rigorous manner to all data sets generated Excellent written and oral communication skills and interpersonal skills that enable effective team interactions and communication of key data to all key stakeholders A strong ability to collaborate cross-functionally in a multidisciplinary environment is critical Capability to deliver high quality manuscripts, posters and presentations for internal and external peer-reviewed publication and conference attendance. Understanding of human genetics and genomic data mining for target identification are a plus. What you can expect of us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models, including remote and hybrid work arrangements, where possible Apply now for a career that defies imagination Objects in your future are closer than they appear. Join us. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Salary Range 135,729.00 USD - 168,454.00 USD About Us Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential. #J-18808-Ljbffr

Atoco, Inc. is a startup company founded by the distinguished scientist Prof. Omar Yaghi, the inventor of MOF and COF chemistry. Atoco is currently working on technologies in the fields of atmospheric water harvesting and CO2 capture. This position will join the initial startup team that will be working on commercialization of technologies from the University of California, Berkeley. This position will focus on the design and scale up of systems that improve their overall performance in adsorbing/desorbing water vapor. Roles and Responsibilities Work with and report to the head of Product Engineering to achieve the department goals of scaling up commercial-grade MOF/COF-based atmospheric water harvesting technology. Collaborate closely with R&D scientists to process the technical and functional specifications of MOF/COFs coming out of the R&D. Responsible for the system-level design and development of the heat management system, including optimization of heat exchangers, thermal storage, optimization of fluids transfer, pumps, fans, and filters that will operate on the MOF/COFs. Design, plan and scale up the technologies from prototype stage to commercial stage. Identify and optimize critical component and system-level parameters to improve overall product performance in terms of production capacity, energy efficiency, lifetime (reliability/durability), yield, cost, safety, and operation. Evaluate and manage sourcing of materials and components, taking into consideration the whole process from sourcing to final assembly and packaging. Help set up the QC/QA processes and procedures for production. Maintain an electronic notebook detailing all observations and measurements. Contribute to the intellectual property of the company by writing and participating in invention disclosures. Perform periodic reporting to management and participate in technical meetings. Qualifications PhD in mechanical engineering or similar field from an accredited institution, along with a demonstrated record of achievement in research. Strong understanding of thermodynamics, fluid mechanics, and heat transfer. More than 5 years of industrial R&D experience. Industry experience in designing system-level prototypes. Experience in simulation tools for thermal design, thermal analysis, and energy performance Familiar with health and safety procedures in production. Thrive in a culture that values diversity, collaboration, precision, and learning. Strong teamwork and collaboration skills. Excellent problem-solving skills. A track record of successful scale-up prototypes or experimentation. Effective written and verbal communication skills.

Candidates must be US citizens or US permanent residents as required by Government regulations for this position. MetroLaser, Inc. is a leading R & D company world-wide recognized for its laser-based measurement and diagnostic technologies for industrial, military, and space applications. Since its inception in 1988, MetroLaser has been at the forefront of state-of-the-art research and development as well as the commercialization of optical diagnostics systems to measure flow velocity, temperature, chemical composition, surface temperature, non-destructive inspection of components, etc. The core business of MetroLaser is in the defense sector, NASA and DOE and as a commercial provider of flow and combustion diagnostics. We have an exciting opening for a Holography Applications Scientist at our office in Laguna Hills, CA. The new appointee will support the scientific staff in implementation, investigation and analysis of laboratory-based experiments and various engineering problems. The successful candidate is expected to work under moderate supervision while using technical skills and judgment to solve problems encountered during the course of the experimental/analytical investigation. The appointee is expected to prioritize time to stay on schedule, be proactive in documenting the results and findings, and in communicating them to the scientific staff. He/she is expected to work as a part of a team and may also lead efforts with other engineers and technicians. Job Responsibilities Design, analysis and construction of optical systems using holography for measurements, right from inception to prototyping Application of holography for microscopy and microbial tracking for plant biology Application of holography for measurements in fluid mechanics and particle dynamics Interfacing holography with fluorescence-based spectroscopy Develop timelines and resources to implement solutions for the project execution Layout of breadboard for experimental work and instrument development Document findings/results and analyses for reporting Interface with other technical stuff to jointly investigate and solve engineering problems Prepare technical presentations for internal use, conferences and customers Qualifications MS/Ph.D. in optical sciences/engineering, mechanical/aerospace/structural engineering or equivalent, with 1 or more years of work experience after the PhD degree or 2 or more years of experience after the MS degree Good understanding of optics, lens design, optical systems design Working knowledge of holography, interferometry and Schlieren for instrument development and applications Good understanding of fluid mechanics and structural mechanics Good understanding of microbial tracking in plant biology Experience with lasers and optical detectors Experience with Zemax or a similar optical design software Experience in image processing and software coding using C/C++/Python/MATLAB Experience with LabVIEW and SOLIDWORKS programming Highly-motivated and a self-starter with ability to quickly absorb new concepts and subsequent application within prescribed timelines and resources Strong communication and inter-personal skills, and the ability to work in a team towards a larger company objective MetroLaser, Inc. offers highly competitive compensation and fringe benefit package that includes retirement plan, matching contributions; health, dental and vision benefits; generous paid time-offs; sick leaves and a highly intellectual, work environment. MetroLaser is an equal opportunity employer. Candidates must be US citizens or US permanent residents as required by Government regulations for this position .

Check our personal care site: Innovative Raw Materials For The Personal Care Industry | Omya BASIC FUNCTION: To help promote sales growth and provide application support to our sales team, customers, and supply partners. To enhance the technical knowledge of our sales team and support customer formulation requests through an in-depth knowledge of our diverse ingredient portfolio. To support innovative prototype development of unique formulation concepts that showcase our portfolio while aligning with and driving market trends. RESPONSIBILITIES: Support prototype formulation, customer co-development projects, and lab activities. Ensure laboratory is stocked with the necessary raw materials, equipment, and documentation. Keep detailed records of formulations, processing techniques, and stability data. Troubleshooting customer and prototype formulations. Support research projects to further understand portfolio synergies. Participate in industry trade shows and meetings. Develop a network of key contacts within the Personal Care industry. Proactively communicate ideas, innovations, synergies, projects, and timelines. Support a safe, organized, and efficient lab environment. QUALIFICATIONS: Bachelor's Degree in Chemistry or related technical field and at least 3 years of bench formulating experience in skin care, hair care, sun care and color cosmetics, etc. Contract manufacturing experience preferred, with a working knowledge of formulation challenges, final product scale-up and manufacturing equipment. Good knowledge of key Personal Care raw material chemistries and suppliers of cosmetic science. Experience with regulatory requirements as they relate to cosmetic/personal care ingredients and formulations. Organized, detail oriented with excellent time management skills. Excellent written and verbal communication skills with the ability to interact with supply partners, customers, and colleagues at all levels. Resourceful and Independent self-starter, with excellent problem-solving skills, able to see tasks through to completion. Able to travel (10-20%). Salary range: $60,000 to $75,000 USD. Must possess current US employment authorization; sponsorship not available for this position. EOE

The Food Scientist plays a key role in developing best-in-class scratch-quality food products for Haliburton's food service, and industrial and retail customers. The ideal candidate is naturally passionate about food and food science understanding the balance between product design and profitability. The Food Scientist works actively with cross-functional teams collaborating on new product designs and providing technical support. The Food Scientist thrives working as a member of a team and prefers open communication and a fast-paced work environment. Essential Duties & Job Responsibilities Is capable of developing commercially viable, profitable product prototypes for a variety of product lines including kettle-cooked sauces, roasted vegetables, pickled vegetables, IQF grains and beans, salsas, hot and cold process condiments, dips, and spreads Relies on science to support assertions when troubleshooting or conducting root cause analysis. Strong working knowledge and proven track record of successful product “matching” Culinary-centric, food-savvy, and passionate about food, food science, and product development Stays current with respect to industry awareness, food trends, and product development innovation Ensures work tasks are documented according to company and regulatory standard Has a thorough understanding of food preservation methods, can execute a variety of sensory tests including preference and triangle Competent in physical chemistry testing including salt, pH, Brix, water activity, viscosity, and acid Supports continuous improvement initiatives working on cost optimization, process improvement, product design, ingredient sourcing, and cross-utilization projects Has a general understanding of microbiology Understands food safety consistent with the FDA food code Becomes a subject matter expert relative to Haliburton's processing and product capabilities Capable of developing solid working relationships with customer contacts through rapport building, earning trust, and being the customer's “go-to” R&D contact Leads customer R&D work sessions and attends customer meetings as assigned Collaborates and works with cross-functional teams in a productive, professional, and thoughtful way Maintains an exceptionally clean workspace, practicing “clean as you go” standard at all times including departmental appearance, behavior, and attitude standards. Executes product development projects in a manner consistent with Haliburton's quality and professionalism expectation Is able to translate customer “kitchen recipes” into working R&D formulas Adheres to and models good manufacturing practices (GMPS) whenever in the plant Minimum Qualification Requirements Education and Experience Bachelor's degree in food science required Associates degree or continuing education in culinary arts preferred 4 years of experience as a food scientist working in a related food manufacturing environment required 2 years of experience designing kettle-cooked shelf-stable, refrigerated, and frozen sauces required Demonstrates proficiency in knife handling and basic cooking techniques Strong knowledge of sensory testing Communication, Interpersonal and Professional Skills Exceptional business-level has written and verbal communication skills Must be an attentive listener Interacts well with customers including purchasing, development, and quality executives Is direct and to the point. Recognizes the value of time when communicating Is highly motivated and willing to “manage up” by providing leadership with honest feedback Organizational Skills Must demonstrate exemplary planning and time management skills Must be detail-oriented Can seamlessly manage multiple projects with tight deadlines Utilizes Outlook calendar for planning and scheduling Initiative & Creativity Possesses an acute sense of urgency in recognizing customer needs in a proactive way Is a highly motivated self-starter that is a solution-oriented problem-solver Demonstrates creativity through recommendations, input, and project results Computer Skills Must be well versed and demonstrate competency in Microsoft Word, Excel, PowerPoint, Access, Outlook, Adobe, and other computer applications as needed Prior experience and fluency with Genesis, ERP, and PLM systems preferred Mathematical Skills Proficient in addition, subtraction, division, multiplication, ratios, and percentages Physical Demands/work environment Able to sit and work at computer work station up to 30% of the time Able to stand and walk up to 70% of the time Able to work in a fast-paced environment Willing and able to participate in plant trials and runs as needed Withstand strong odors from the foods being processed

Job Description: Contract to Hire We are seeking a detail-oriented QC Chemist to join a leading pharmaceutical company. This role will involve testing raw materials, in-process samples, and finished products to ensure compliance with GMP and regulatory standards. Key Responsibilities: Conduct chemical and physical testing (HPLC, GC, etc.) on raw materials and finished products. Analyze and record data, preparing Certificates of Analysis (COA). Support stability studies, method validation, and troubleshooting of lab equipment. Ensure compliance with GMP, GLP, and FDA regulations. Assist in investigations of OOS results and CAPA activities. Qualifications: Bachelor's degree in Chemistry or related field. 2+ years of QC experience in the pharmaceutical industry. Knowledge of GMP, FDA regulations, and laboratory techniques. Strong attention to detail and problem-solving skills.

AcuraStem is a patient-based biotechnology company pioneering the development of treatments for amyotrophic lateral sclerosis (ALS), Frontotemporal dementia (FTD), and additional neurodegenerative diseases. We are a purpose-driven company on a mission to get our promising treatments into patients' hands as quickly as possible. AcuraStem's best-in-class disease modeling platform, iNeuroRx , is the gold standard for discovering novel, effective, and broadly-acting treatments. The AcuraStem team's extensive expertise in ASO technology is accelerating the advancement of treatments to the clinic. At AcuraStem, we know that empowered and supported colleagues strengthen our commitment and significantly enhance our collective mission. We are committed to scientific excellence, impactful results, persistence, attention to detail, teamwork, sound decision-making, and continuous learning. We are seeking a highly skilled and well-organized Senior Research Associate to contribute to our research programs and drive scientific progress. The Senior Research Associate will work closely with AcuraStem scientists, executing and refining experimental protocols with precision. The ideal candidate will have experience handling rodents and be adept at following detailed protocols meticulously while also demonstrating the ability to propose improvements when necessary. Responsibilities: Design, execute and manage in vivo experiments assessing the efficacy and safety of test agents in various rodent models. Perform a range of in vivo techniques, including rodent handling, various routes of compound administration (IV, ICV, IT), tissue collection, and behavioral assessments. Manage mouse colonies and perform breeding, weaning, and genotyping. Conduct various laboratory assays, including immunohistochemistry, microscopy, and biochemistry/molecular biology. Analyze and interpret experimental data, and prepare scientific documents including study reports, protocols, and other related materials for presentations, regulatory submissions and publications. Maintain accurate records of experimental data and protocols in accordance with AcuraStem guidelines. Collaborate effectively with internal/external resources to schedule and execute tasks independently with minimal training/guidance from manager. Independently conducts multiple complex experiments and provides technical guidance and problem solving related to methods, procedures and processes, and obtain optimum solutions. Provide technical guidance and problem-solving related to methods, procedures, and processes to the work group. Mentor and train junior lab members, promoting a positive and collaborative research environment. Desired Skills and Experience: Minimum 6+ years of hands-on experience conducting in vivo research with mice or rats. B.S. in Biology, Neuroscience, Bioengineering, or a related discipline, with 4+ years of industry experience or 6+ years of academic research experience. Strong verbal and written communication skills for effective collaboration and documentation. Strong organizational and analytical skills to manage multiple projects simultaneously. Proven ability to work effectively both independently and as part of a team. Knowledge of and adherence to Environmental Health & Safety (EH&S) procedures. Additional Information: Scheduling Flexibility: Availability for late evening, weekend, and holiday work as needed to support animal welfare needs. Travel Requirement: Frequent travel (>50%) to various AcuraStem laboratory sites in Los Angeles. Work Authorization: Candidate must be currently in the USA and authorized to work immediately. Compensation/Benefits: The salary range for this position is $82,000 - $115,000 with actual compensation determined by factors such as experience, qualifications, location, and other role-specific requirements. AcuraStem offers a comprehensive and competitive benefits package tailored to attract top talent. All regular-status employees receive compensation, performance-based bonuses, equity, and extensive benefits, including health, dental, vision, life, and disability insurance. AcuraStem also provides paid time off, annual company holidays, 401K matching, and bi-weekly lunch for onsite staff. Diversity, Inclusion, and Recruitment Practices at AcuraStem: Applicants must be authorized to work in the United States. AcuraStem is an equal-opportunity employer and values diversity and inclusion throughout the hiring process. Employment decisions are made based on relevant qualifications, experience, and business needs, without regard to race, color, religion, sex, gender identity, sexual orientation, age, marital status, national origin, disability, veteran status, or any other protected characteristic. AcuraStem's commitment to diversity and inclusion extends to all areas of employment, including hiring, compensation, performance evaluations, promotions, training, and career development. We strive to provide a supportive and inclusive workplace, free from discrimination or harassment. For staffing inquiries, AcuraStem's Human Resources team manages all recruitment activities directly. We ask that external recruiters avoid contacting hiring managers or submitting candidates without prior authorization, as unsolicited resumes will not establish any contractual relationship with AcuraStem. Qualified candidates, please submit your CV/resume to ******************

KPG Allied is seeking a travel Clinical Lab Scientist (CLS) for a travel job in Los Angeles, California. Job Description & Requirements Specialty: Clinical Lab Scientist (CLS) Discipline: Allied Health Professional Duration: 52 weeks 40 hours per week Shift: 8 hours, evenings, nights Employment Type: Travel Certifications: CA License, BLS, ASCP Start Date: ASAP Shift Time: Nights Shift Length: 5x 8hr Assignment Length: Ongoing Notes: Must have a 2 years paid experience in a Hospital Setting. Blood Bank experience a plus!. Must be able to confidently work independently. About KPG Allied What KPG Healthcare can offer you: 8, 13, 26 week assignment Competitive Compensation Package Nationwide contract opportunities Housing or Housing stipend provided Travel and License reimbursement Healthcare benefits Recruiter available 24/7 Weekly Pay with direct deposit KPG Healthcare: KPG Healthcare is a Staffing Firm that provides diverse Supplemental and Permanent Healthcare Staffing solutions to a wide range of Clients throughout the Nation. Our Services include Travel Nursing, Allied Professionals, Per Diem Nurse Staffing, Locum Tenens Staffing and Physician Placement. The primary factor differentiating KPG Healthcare from other recruitment firms is the quality of our experience, the breadth of our industry network, and the creativity that we apply to finding the perfect placement options. Throughout our partnership with you, we will excel at providing friendly personal attention and producing outstanding results.

Join Amgen's Mission of Serving Patients At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do. Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Principal Scientist - Cardiometabolic DisordersWhat you will do Let's do this. Let's change the world. We are building upon our solid Cardiovascular foundation and long-term dedication to patients by developing a whole new class of novel molecules - and we need top talent to ensure these molecules become medicines and realize their potential for helping patients. We are seeking a dedicated and highly motivated Principal Scientist to become a member of the Department of Cardiometabolic Disorders within Amgen Research located in Thousand Oaks, CA. In this vital and exciting role you will be an ideator and drug hunter and are expected to conduct biology research and identify therapeutic targets in cardiometabolic disease that are tractable and offer the opportunity of delivering disease-modifying potential in patients. The proposal and advancement of a drug discovery program will be based on a sound and compelling scientific rationale that may include validation from human genetics and/or clinical studies. Critical thinking, ingenuity, the ability to design and conduct mechanistic studies and deep biology, technical proficiency, excellent communication skills, integrity and the ability to work in a multi-disciplinary environment will be critical toward advancing programs in the cardiometabolic pipeline. You will initially work at the bench conducting in vivo and/or in vitro preclinical studies with a focus on PAH, vascular disease and/or heart failure. Over time, you will also demonstrate strong leadership skills and the ability to manage a team of scientists conducting drug discovery research. As part of the team, the candidate may also support other new and existing drug discovery programs in the department to help advance the best assets in the Cardiometabolic Disorders portfolio. Conceptualizing and proposing therapeutic targets for the treatment of cardiometabolic disease Designing and performing in vitro and cell-based experiments Independently performing data analysis and interpreting results Communicating scientific results through written and oral presentations Collaborating with teams from other functions in the company to advance our programs Documenting work through written protocols, electronic laboratory notebooks and study reports. Advising colleagues in areas of expertise What we expect of you We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a scientist with these qualifications. Basic Qualifications: Doctorate degree and 2 years of scientific experience Or Master's degree and 5 years of scientific experience Or Bachelor's degree and 7 years of scientific experience Preferred Qualifications: PhD with postdoctoral experience in cardiometabolic disease (industry experience is strongly preferred) Strong target ideation capabilities and critical thinking to enable discovery of innovative medicines for patients Exceptional in vivo and/or in vitro pharmacology skills and capability to independently design, implement and analyze studies with proper controls and generate reproducible high-quality data Technical mastery of general molecular biology, biochemical, and cell-signaling techniques including immunoblotting, immunocytochemistry, RT-qPCR, immunoprecipitation, and ELISA Basic knowledge of statistical methods applied in a consistent and rigorous manner to all data sets generated Excellent written and oral communication skills and interpersonal skills that enable effective team interactions and communication of key data to all key stakeholders A strong ability to collaborate cross-functionally in a multidisciplinary environment is critical Capability to deliver high quality manuscripts, posters and presentations for internal and external peer-reviewed publication and conference attendance. Understanding of human genetics and genomic data mining for target identification are a plus. What you can expect of us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models, including remote and hybrid work arrangements, where possible Apply now for a career that defies imagination Objects in your future are closer than they appear. Join us. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. #J-18808-Ljbffr