Ardelyx develops novel, first-in-class oral therapeutics to correct mineral metabolism and metabolic disorders. The Company's molecules, whose systemic exposure is severely restricted, target transporters and receptors, modulating the uptake of nutrients or inducing secretion of key hormones to produce a therapeutic benefit in patients. The Company's non-systemic products act from within the intestines to avoid potential side effects that could occur with systemic exposure. The Company's lead product, RDX5791, a minimally-absorbed, orally administered NHE3 sodium transport inhibitor, is being developed both for constipation-predominant irritable bowel syndrome (IBS-C) and for prevention of excess dietary sodium absorption, a new treatment modality for high blood pressure. RDX5791 is in phase 2 for IBS-C and a dose-ranging/regimen study for inhibition of excess dietary sodium absorption. Ardelyx is also developing RDX002, a minimally-absorbed, orally administered NaP2b phosphate transport inhibitor for the inhibition of phosphate absorption in patients with chronic kidney disease, and RDX009, a minimally-absorbed, orally administered TGR5 agonist for the treatment of type 2 diabetes through direct induction of intestinal incretins such as GLP-1 and PYY. Both RDX002 and RDX009 are in preclinical development. To date, Ardelyx has raised $56M in venture and angel funding since it was founded in 2007. Ardelyx is located in Fremont, California.Ardelyx is a small health care company based in Fremont, CA with only 86 employees and an annual revenue of $52.0M.
Ardelyx's Mission Statement
We are dedicated to improving the lives of patients by discovering, developing and commercializing first-in-class targeted therapies that advance patient care.
The founders of Ardelyx are Dominique Charmot and Peter Schultz.
The key people at Ardelyx are Michael G. Raab, Dominique Charmot and Peter Schultz.
Key People
M
Michael G. Raab
D
Dominique Charmot
P
Peter Schultz
Ardelyx Rankings
Ardelyx is ranked #9 on the Best Health Care Companies to Work For in Fremont, CA list. Zippia's Best Places to Work lists provide unbiased, data-based evaluations of companies. Rankings are based on government and proprietary data on salaries, company financial health, and employee diversity.
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Ardelyx may also be known as or be related to ARDELYX INC., ARDELYX, INC., Ardelyx, Ardelyx Inc and Ardelyx, Inc.