Alector Jobs

Our mission is to develop therapies that empower the immune system to combat neurodegeneration and our team is focused on developing treatments for some of the most challenging diseases facing our society. By harnessing advancements in genetics, immunology and neuroscience, we are pioneering the development of potential therapies to counteract the devastating progression of neurodegeneration. We are supported in this mission by experienced and accomplished scientists and clinicians, a novel portfolio of programs, leading healthcare investors, and pharma company partners, who share in our commitment to bettering the lives of patients and realizing a world where we make brain disorders history. The Senior Director of Nonclinical Science will provide scientific leadership and strategic oversight in Nonclinical evaluations of Alector pipeline programs. The successful candidate will work in close partnership with Research and Development teams to facilitate seamless execution. During your first year, you will: Lead and supervise the Toxicology and BioAnalytical teams Provide strategic guidance on Nonclinical evaluations of pipeline programs. Design, execute Nonclinical studies and interpret study results together with the Toxicology team to advance programs.Oversee the preparation, review and approval of Nonclinical Regulatory documents and collaborate with the Toxicology and Regulatory teams for interactions with Health AuthoritiesSupervise the BioAnalytical team for PK/PD/ADA assay development to support clinical programs, nonclinical programs and early stage research programs.Manage Nonclinical budget, FTE and other internal and external resources effectively to ensure program timelines, goals and priorities are met Establish and maintain close partnership with key collaborators across the organization to drive programs forward, contribute to a team culture that promotes ownership, collabration and perseverance. We would love to hear from you if: PhD in Toxicology or related scientific field, with at least 15+ years of post-training experience in academia, biotech or pharma. Industry experience in drug discovery and development required Demonstrated leadership and expertise in non-clinical safety and a broad understanding of toxicology/pathology, bioanalytical, ADME, regulatory and clinical pharmacology.Proven ability to lead and collaborate on multi-function project teams, providing scientific and strategic direction to advance drug candidates from preclinical stage into clinical trials.Desire to work in a fast-paced environment with can-do attitude.Exceptional critical thinking and decision making skills Exceptional oral presentation and written communication skills $262,080 - $283,466 a year Base salary ranges will be determined by the candidate's level, qualifications, skill set, and experience. #LI-BL1 #LI-Onsite At Alector, our vision is bold, people are our priority, and our values are at the core of everything we do. Our dynamic and flexible environment encourages our teams to experiment, take ownership of decisions, and question convention to solve complex problems. We value shared wins, perseverance, and a growth mindset, which drives us forward, together. Among the things you'll discover at Alector from your very first day are our committed and driven colleagues, a bold company vision, and new, modern offices designed to inspire innovation and collaboration in South San Francisco, right at the heart of Biotech Bay. Our benefits are thoughtfully designed around Alectorians and their loved ones and include flexible hybrid work options, competitive compensation, and comprehensive and unique benefits that enhance your health and well-being. Come join us! We believe that hard-working teams include people from a wide variety of backgrounds and experiences who can challenge each other's assumptions with fresh perspectives and bring creative ideas to the table. We are committed to building an open, diverse, and inclusive environment for all employees. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, sexual orientation, age, marital status, veteran status, or disability status, or any other characteristics protected under applicable federal, state, or local laws. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, perform essential job functions, and receive other benefits and privileges of employment. Please contact us to request accommodation. Review our Privacy Policy

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. Executive Director, Head of Payer Field Team will lead efforts ensuring robust formulary status, access, and coverage for its innovative medicines. This leadership role will manage a nimble, focused team responsible for engaging National and Regional Payers, Pharmacy Benefit Managers (PBMs), Medicaid programs, Medicare Administrative Contractors (MACs), the VA/DoD, and other relevant payer related entities. The successful candidate will bring expertise in payer strategy, industry relationships with major payers, relationship management, negotiations, rare disease, and market access for innovative medicines reimbursed through both medical and pharmacy benefits. As part of an emerging biopharma company, the ideal candidate will thrive in a resource efficient environment, balance strategic vision with tactical execution, and foster a collaborative, patient-focused culture. Key Accountabilities/Core Job Responsibilities: Payer Engagement and Strategy: Develop payer strategies to secure favorable formulary status, access, and coverage for the Denali's medicines across all relevant payer segments including Denali's first US launch in MPS II, Hunter syndrome, with tividenofusp alfa. Build and maintain strong relationships with National and Regional Payers, PBMs, Medicaid programs, MACs, VA/DoD, and other key stakeholders. Partner with internal stakeholders including sales and marketing to address coverage challenges and optimize reimbursement. Initially serve as the primary contact for all payers with the intention of ultimately developing the expansion plan for the Payer Team to eventually include additional account managers Leadership and Team Management: Hire, lead, mentor, and develop a high-performing payer field team with a focus on strategic engagement and execution, including annual goal setting, growth planning, adherence to company policies, maintain training compliance and provide ongoing feedback on growth, development and areas of improvement Set clear objectives and performance metrics aligned with organizational goals for payer access, reimbursement and profitability. Cross-Functional Collaboration: Work closely with market access, trade and distribution, sales & marketing, medical affairs, and commercial teams to align payer strategies with broader business objectives. Align and partner with field sales on robust pull through and push through strategies. Provide actionable insights to internal stakeholders based on payer feedback and trends. Contribute as appropriate with clinical operations, technical operations and medical affairs on all topics that may impact access and coverage decisions to be made by payers (e.g. BIM model, RWE, product packaging…). Policy and Market Expertise: Stay current on payer policy changes, regulatory developments, and market trends impacting Denali's medicines, competitive products, and general patient access. Serve as a subject matter expert on reimbursement, access, and coverage for internal and external stakeholders. Operational Excellence: Oversee team engagement with payers, ensuring compliance with company policies and industry regulations. Develop tools, resources, and training to support the team's effectiveness in payer interactions and negotiation outcomes. Qualifications Bachelor's degree in business, healthcare, or related field (MBA or advanced degree preferred). 15+ years of relevant experience, including 10+ years in market access, payer relations, and reimbursement strategy, with a focus on rare diseases and/or innovative medicines. Proven track record effectively managing National and Regional Payers, PBMs, Medicaid, Medicare, and VA/DoD accounts while delivering exceptional medicine access and profitability. Strong leadership and team management skills, with at or near 12 years experience coaching and developing others, including direct and indirect reports. Exceptional communication, negotiation, and relationship-building skills. Comprehensive understanding of payer policies, formulary management, and reimbursement processes. Ability to synthesize complex information and provide strategic insights to guide decision-making. Critical Success Factors Strategic Vision and Execution: Capable of shaping long-term payer strategies while delivering measurable short-term results. Collaboration and Influence: Skilled at fostering cross-functional collaboration and influencing internal and external stakeholders. This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. This position is required to be based in San Francisco, CA. Key Accountabilities/Core Job Responsibilities Legal Compliance: Advise on employment laws applicable to Denali's California, Utah, and Switzerland offices and remote employees, including wage and hour regulations, anti-discrimination laws, and leave policies. Policy Development: Draft, review, and update employee handbooks, workplace policies, and SOPs to ensure compliance and alignment with Denali culture. Employee Relations: Partner with HR to provide guidance on complex employee relations issues, investigations, and performance management. Litigation and Risk Management: Manage and oversee the resolution of employment-related disputes and coordinate responses to agencies. Hiring and Onboarding: Support the development of compliant hiring practices, offer letters, and onboarding materials. Training: Develop and deliver training programs for managers and employees on employment law topics, including performance feedback, leave policies, and workplace conduct. Immigration Oversight: Oversee and support immigration matters, manage relationships with immigration counsel, and ensure timely and efficient outcomes. Cross-Functional Support: Collaborate with teams on employment-related aspects of business strategies, including international expansion and benefits. Support the establishment of a strong, integrated culture across sites. Skills/Qualifications: J.D. degree from an accredited law school. Active California bar membership in good standing. 7+ years of relevant work experience. Expertise in U.S. federal, state, and local employment laws and regulations required; familiarity with Swiss employment law preferred. Proven experience advising on employee relations, policy development, and compliance. Experience in the biotech, life sciences, or technology sectors preferred. Strong project management skills and ability to prioritize in a fast-paced environment. Exceptional verbal and written communication skills, the ability to communicate with tact and diplomacy, and a deep, abiding sense of compassion and integrity. Growth mindset, with a willingness to learn new things, expand outside boundaries, and broaden areas of expertise. No task is too big or too small. Ability to thrive efficiently in a fast-paced environment, managing a heavy workload at times and adapting quickly to change. Excellent judgment, complemented by an awareness of when to seek guidance and collaboration. Willingness to courageously and clearly identify risks and seek solutions. A proven record of building trust and credibility through consistent and reliable partnerships with business functions. Salary Range: $225,000.00 to $272,000.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at ****************************************** This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. Key Accountabilities/Core Job Responsibilities: * Distribution Management: * Build and maintain strong partnerships with 3PLs, specialty distributors, specialty pharmacies, and customers. * Oversee the performance of distribution partners to ensure efficient and compliant operations including quarterly business reviews (QBRs). * Develop strategies to support medicine launches, ensure supply continuity, and address distribution challenges. * Data Flow, SAP integration & Reporting: * Serve as the Denali commercial representative on its SAP implementation team. * Lead the integration and optimization of channel operations workflows within the SAP ERP system, ensuring alignment with commercial, accounting, and gross-to-net processes. * Manage inventory, sales, and chargeback data flows to ensure timely and accurate information sharing across stakeholders and systems. * Collaborate with and manage outsourced vendors to ensure high-quality data integration, aggregation, analytics, and reporting services. * Provide data-driven insights to inform decision-making and support market access strategies. * Contract Administration: * Administer any contract related payments with 3PLs, specialty distributors, specialty pharmacies and customers. * Ensure accuracy and classification of contract-related payments for partners and help ensure data structures and data flows provide for government price reporting accuracy and compliance. * Ensure documentation and secure database for all contract related contracts, SOP's, and payments and that customers receive accurate contract pricing. * Operational Oversight: * Monitor performance metrics and contractual compliance for distribution partners and outsourced vendors. * Drive continuous improvement initiatives to optimize the distribution model, contract administration process and enhance efficiencies. * Ensure adherence to regulatory requirements and industry standards. * Cross-Functional Collaboration: * Partner with internal teams, including supply chain, government price reporting lead, commercial, regulatory, and finance, to align distribution activities with organizational goals and help ensure compliance. * Serve as a key point of contact for resolving distribution-related issues and fostering teamwork across functions. * Contribute as appropriate with technical operations and the supply chain team on all topics that may impact product packaging. * Act as a key contact for external auditors, responding to inquiries and data requests, and assisting in resolution of discrepancies. Prepare and maintain audit-ready documentation to support SOX compliance and other regulatory requirements. Qualifications * Bachelor's degree in business, supply chain, or related field (MBA or advanced degree preferred). * 7+ years of experience in channel operations, distribution, and supply chain within the biopharma or healthcare industry. * Experience managing relationships with 3PLs, specialty distributors, and specialty pharmacies. * Strong knowledge of data management, including inventory, sales, and chargeback processes. * Experience with administering distribution and customer related contracts. * Experience with ERP systems including SAP * Familiarity with rare disease markets and the unique challenges of patients with rare diseases. * Exceptional project management, analytical, and problem-solving skills. * Excellent communication and interpersonal skills with a collaborative mindset. Critical Success Factors * Flexibility and Agility: Ability to thrive in a fast-paced, efficient environment and manage competing priorities. * Strategic and Tactical Balance: Capable of shaping long-term strategies while executing operational details effectively. * Team Player: Willingness to collaborate across functions and contribute to a positive, solution-oriented culture. * Proactive Mindset: Anticipates challenges, seeks innovative solutions, and takes initiative to improve processes. This is a unique opportunity to play a key role in the success of Denali which is dedicated to making a difference in the lives of patients. Salary Range: $183,000.00 to $232,333.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at ****************************************** This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. The Senior MSL is a field-based representative of the medical affairs team, primarily responsible for advancing scientific and collaborative relationships with key healthcare providers (HCPs) and decision makers within a defined geography via timely knowledge exchange of accurate, scientific, and non-promotional information to enable optimized patient outcomes. Key Accountabilities/Core Job Responsibilities: Identify and develop strong scientific relationships with HCPs within a defined territory and provide credible, and fair-balanced information about Denali's research activities and product development Respond to unsolicited medical and scientific requests for medical information in a compliant and timely manner Provide clinical trial support to identify potential new sites, resolve issues with enrolling sites, and participate in investigator meetings, as appropriate; liaise with R&D, Medical Affairs, and Clinical Operations teams Provide scientific presentations at company sponsored and external meetings, as needed Develop and maintain a high level of therapeutic area, disease state and product expertise Participate in national and regional medical/scientific meetings and symposia to engage with attendees, attend scientific sessions and poster presentations, and gather clinical and business insights to share with internal cross-functional teams. Lead and/or participate in training, and other internal efforts to support medical objectives; may serve as a training lead Appropriately document interactions and act in accordance with company policies and guidelines Qualifications/Skills: Doctorate level degree is required (PharmD or PhD); MD degree preferred Specialty training in rare disease and/or neuroscience preferred 5+ years of relevant work experience, including 3+ years in an MSL role in the in the pharmaceutical/biotech industry Knowledge of current regulatory guidelines to ensure corporate compliance in all activities, including those related to scientific interactions, unsolicited questions and clinical trials and research. Excellent interpersonal and communication skills with the ability to effectively present scientific and medical information to diverse audiences, including HCPs, researchers, payors, patients and industry colleagues. Ability and willingness to travel up to 75% including overnight travel to accomplish field scientific responsibilities. This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. The Senior Project Admin Coordinator, oversees activities for senior leadership, including managing complex calendars, organizing meetings, and arranging travel logistics. They serve as a primary point of contact for various meetings, events, presentations and projects. Key Accountabilities/Core Job Responsibilities: Confidentially coordinate activities for assigned members of Denali Senior Leadership. This includes management of a complex calendar(s) and organizing BOD, advisory and investor meetings when required. Coordinate travel arrangements and associated logistics with shifting priorities and deadlines. Plan and organize meetings, prepare agendas, provide research and background information, create presentations and coordinate all logistics. Represent Senior Leadership to external constituencies by serving as the primary point of contact and assessing requests and questions. Make autonomous, accurate and swift judgments, including forwarding questions and requests to other senior staff. Prepare Senior Leadership for internal/external meetings by researching organizations and individuals, bringing together resources to aid in preparation, and compiling relevant materials. Anticipate the business needs for Denali Senior Leadership and senior team by proactively formulating and evaluating solutions and/or recommendations to facilitate meeting deadlines and achieving goals. Compose correspondence. Develop, review, and edit presentations and documentation. Independently research and analyze associated issues and/or compile materials needed for presentation and/or decision-making purposes. Manage multiple projects simultaneously. Anticipate and track initial dates, events, and associated action items; follow up with appropriate parties on behalf of supervisor to ensure deadlines are met. Support event planning and execution. Maintain accurate and timely recording of work time by clocking in and out using designated timekeeping systems. Adherence to company timekeeping policies, including rules regarding overtime, meal breaks, and reporting procedures for any discrepancies. Qualifications/Skills: High school diploma or equivalent and 5+ years of administrative support experience required Proven track record of supporting senior-level leadership Demonstrated ability to handle sensitive issues and maintain the utmost confidentiality Demonstrated ability to perform duties with a high level of professionalism, flexibility, discretion, judgment, diplomacy, and tact Exemplary internal and external interpersonal and customer service skills Ability to multitask, adapt to changing priorities and deadlines Advanced computer skills and demonstrated experience with office software and G-Suite Excellent verbal and written communication skills, including editing and proofreading Growth mindset with interest and curiosity to learn new things Ability to adapt to changes in a rapidly scaling organization Excellent planning and organizational skills Ability to take initiative and ownership of projects Preferred Qualifications Bachelor's degree Biotech industry experience Previous experience working for a global organization Hourly Range: $45.67 to $55.05 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at ****************************************** This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. We are seeking to recruit an experienced Manager, Corporate Finance and Accounting to enhance the Company's finance function and become a key part of the team as we grow to support the business. This role will be responsible for overseeing and managing the operational accounts payable function and various other general ledger functions, as well as being a key contributor in the financial close process. This colleague will play a key role in establishing and maintaining a strong internal controls over the Company's accounts payable and cash processes. This is a hands-on working position that will also be responsible for assisting in the day-to-day management of the outsourced accounts payable team to ensure that invoices and payments are properly and timely processed. Key Accountabilities/Core Job Responsibilities: Responsible for day-to-day management of the outsourced accounts payable function Oversee preparation of weekly payment runs in accordance with established SOX processes and the recording in the general ledger all cash outflow transactions and reconcile bank accounts Manage complex and escalated vendor inquiries and requests while overseeing outsourced accounts payable team's responses to routine vendor inquiries Manage, in accordance with SOX and documented policies, response for any unprocessed or failed payments, vendor refunds or credits, and direct debit payments Support or manage other general ledger functions including R&D areas, balance sheet reconciliations, preparing and reviewing journal entries, and analyses as part of the monthly close process Support all accounts payable related annual processes, including annual audits/ quarterly reviews with external auditors, 1099's and other, as needed Assist with user acceptance testing of system and software implementations as needed Assist with the establishment and maintenance of internal controls and SOX 404 compliance Proactively seek ways to improve processes to help reduce time to close, improve accuracy of the underlying accounting records and improve operational efficiency Be able to manage and execute on special projects and support the corporate tax and treasury functions as needed Qualifications/Skills: Bachelor's degree or higher in accounting, finance or equivalent, and 5+ years of professional accounting experience, preferably in the biotech or pharmaceutical industry (without a degree, 8+ years relevant pharmaceutical / biotechnology experience is required) Must be able to demonstrate a thorough understanding of the Procure to Pay process Must be able to demonstrate a high attention to detail with an ability to independently prioritize and organize work assignments. Must possess excellent computer and analytical skills with proficiency in Excel and Word. Good communication skills both oral and written are required. Salary Range: $133,000.00 to $169,000.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at ****************************************** This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. This position will primarily be at the bench to independently conceive, initiate, and direct protein production and related technology development efforts, in alignment with the goals of the Biotherapeutic Discovery organization and responsible for leading the production of large molecule biotherapeutics from milligram to gram scale, including development of robust and scalable purification processes and fit-for-purpose analytics that support the identification and characterization of novel therapeutics Key Accountabilities/Core Job Responsibilities: Develop and troubleshoot protein expression and purification processes for large molecule biotherapeutics. Evaluate and establish technologies to enhance and/or advance protein production and characterization, including high-throughput approaches, in support of Discovery projects, platforms, and pathways. Develop and perform protein purification, biophysical and biochemical characterizations. In this capacity, support and meet timelines for production of a wide variety of proteins, including antibodies, enzymes, Fc-fusions, bioconjugated proteins, and protein complexes. Analyze proteins using standard methods (including HPLC, SEC-MALS, CE-SDS, DLS, DSF, MCE and others). Coordinate activities and work collaboratively with colleagues across Discovery and Development to meet timelines and to help advance programs. Think creatively about ways to integrate novel protein modalities with Denali's BBB-crossing technologies. Actively contribute to project teams and work effectively across functional teams to help advance programs to development. Qualifications/Skills: PhD in Biochemistry or related scientific discipline with >5 years of experience in biotech/biopharma industry; or M.Sc with ≥8; or or B.Sc. ≥12 years of relevant experience, respectively. Extensive knowledge and hands-on experience in the purification and analytical characterization of challenging proteins, complexes and fusion proteins. Demonstrated and documented experience in producing and assessing the purity and activity of complex proteins such as engineered antibodies, Fc-fusions and/or bioconjugated therapeutics. Extensive programming experience of automated liquid handlers and/or protein purification platforms (FPLC/HPLC/robotics). Excellent oral, presentation and written communication skills are required. Ability to work in a highly dynamic and fast paced environment to contribute to multiple projects. Self-motivated with excellent record keeping and written and verbal communication skills. Creative thinker with a strong sense of responsibility and a desire to collaborate in an exciting and fast-paced research environment. Salary Range: $129,000.00 to $181,000.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at ****************************************** This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. This role involves leading a dedicated team within the Development Sciences organization, collaborating with Discovery Sciences, Translational Medicine, and Regulatory teams, and providing scientific and strategic input to advance promising drug candidates to clinical trials. The ideal candidate will possess a strong background in pharmacokinetics, drug disposition, biodistribution, and translational pharmacology, with a proven track record in advancing molecules through CTA/IND milestones to first-in-human clinical trials. Key Accountabilities/Core Job Responsibilities: * Deliver on key Project Team objectives and advance portfolio of blood-brain-barrier penetrant TV biotherapeutics by providing scientific contributions in areas of pharmacokinetics, drug disposition and biodistribution, and translational pharmacology/pharmacodynamics * Lead and manage a group within the Development Sciences organization, providing strategic project-focused vision and oversight to advance drug candidates from Discovery through CTA/IND-enabling studies into Early Clinical Development. * Participate on Project Teams as a subject matter expert contributing to the optimization and selection of lead clinical candidates, and support Group members serving in this role * Design nonclinical PK/PD studies to answer translational questions in support of project deliverables and first-in-human dose predictions; oversee TK analysis for non-GLP and GLP toxicology studies. * Lead Project Teams or Pharmacology Technical Teams in the CTA/IND-enabling stage. * Serve on the Development Sciences Leadership Team; set Function and Organizational goals. * Establish and maintain productive relationships with key partners within the organization, including Discovery Sciences, Bioanalytical Sciences, Safety Assessment, Clinical Pharmacology, Translational Medicine, and Regulatory to advance projects to key decisions and achieve development milestones. * Analyze, interpret, summarize and communicate data to internal project teams, senior management, global health authorities, and strategic partners. * Author and review nonclinical and clinical sections of regulatory filings. * Lead direct report(s) through annual goal setting, growth planning, adherence to company policies, maintain training compliance and provide ongoing feedback on growth, development and areas of improvement. Qualifications/Skills: * A highly motivated individual with a PhD in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology/Toxicology, Engineering, or related field and 10+ years of relevant work experience to include any postdoctoral work; must also have demonstrated experience as a people manager / mentor / coach * Established expertise in biotherapeutic drug disposition and pharmacokinetics, with experience identifying clinical candidates and successfully advancing molecules through CTA/IND milestones to FIH clinical trials. * Proven track record evaluating drug properties that may impact PK, investigating PK/PD relationships, and identifying relevant bioanalytical methods (ligand binding assays, mass spectrometry, or other methodologies) to assess biotherapeutic drug disposition. * Well developed leadership skills in managing groups and developing scientific talent. * Experience serving and/or leading cross-functional Project Teams, with success contributing to data driven decision-making, outlining strategies to enable drug development, and working collaboratively. * Excellent critical thinking and scientific skills, and a demonstrated ability to analyze, interpret, and clearly communicate complex results. * Excellent oral and written communication and presentation skills. Salary Range: $213,000.00 to $255,667.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at ****************************************** This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. The company is seeking an experienced and highly motivated Development Sciences Operations Manager responsible for oversight of technical and operational aspects of Development Sciences workflows, including those conducted at external CRO laboratories in support of Toxicology, Pathology, Biomarker, Bioanalytical, and DMPK/Clinical Pharmacology functions. This individual will work in close collaboration with colleagues in Discovery Research and Development Sciences and will be responsible for working with members of cross-functional teams to liaise with Contract Research Organizations (CROs), monitor studies, manage vendor relationships and contracts, and potentially contribute to the design, execution, and reporting of nonclinical studies for Denali Therapeutics products. Key Accountabilities/Core Job Responsibilities: Serve as Safety Assessment (Toxicology/Pathology), DMPK, Clinical Pharmacology, Biomarker, and Bioanalytical function interface between Denali and external CRO collaborators, developing productive relationships to achieve optimal efficiency in external workflows in GLP, GCP and GCLP areas. Manage identification (RFI), partnering with Legal and Contracts group in managing the operational aspects of pre-clinical contracts and change orders, including active negotiation of scope of work, payment terms and budgets. Manage study operational logistics, including establishing timelines for deliverables, facilitate test material logistics, and support the trafficking of samples, data, and documents Provide support in implementing, managing, and monitoring outsourced nonclinical Toxicology studies (non-GLP and GLP) to support all phases of drug development Remote and onsite oversight of nonclinical studies to ensure studies are conducted to the highest standards Responsible for working with DMPK scientists to identify CRO laboratories capable of conduct of in vitro and in vivo experiments supporting candidate identification and IND-enabling efforts. Engage CROs and internal scientists to outline protocols/SOWs. Receive and review study results and summary reports, ensuring data and reports are integrated into internal databases; help design tools to aid in data upload, migration, and visualization. Ensure compliance with study protocols, IACUC regulations, and SOPs. Qualifications/Skills: BS/MS in Toxicology, Pharmacology, Biological Sciences or related discipline with 3+ years of biopharmaceutical industry experience. Experience working with nonclinical CROs, developing protocols, and an understanding of technical and organizational aspects of study conduct, including knowledge of current animal welfare philosophies and 3Rs. Ability to perform data entry into data warehouses (e.g., Dotmatics/Benchling) and manage data visualization software (Tableau, SEND explorer). Outstanding organization and planning skills, and the ability to assess risks and manage external workflows to meet project team deliverables. Excellent analytical, critical thinking, and soft skills to build collaborative relationships enabling effective professional interactions with vendors and stakeholders. Proven ability to thrive in a collaborative team environment: strong oral and written communication skills, and a helpful team spirit. Salary Range: $133,000.00 to $169,000.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at ****************************************** This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. Key Accountabilities/Core Job Responsibilities: * Independently perform bioassays to support cell-line, bioprocess, and formulation development activities * Assist in the development, optimization, and qualification of assays for product release and stability testing as well as characterization of biological activity. * Support study sample testing, analysis and maintain complete and accurate records and contribute to continuing process improvement * Evaluate, characterize, and document critical reagents to meet QC standards * Coordinate parallel tasks across multiple projects and prioritize deliverables to meet departmental and organizational goals. * Promote innovation and explore novel analytical techniques or technology. Qualifications/Skills: * BS with 3+ years of industry experience or an MS 1+ years relevant experience in the industry * Experience in developing and optimizing bioassays across multiple platforms and technologies (e.g., ELISA, HTRF, DELFIA, fluorescence, etc.) is required. * Strong expertise in nucleic acid techniques, including DNA manipulation, PCR, qPCR, DNA quantification, analysis, and hybrid capture. * Experience in developing or running assays with automated liquid handling systems isa plus. * Proficient in data analysis with Excel and statistical tools such as GraphPad Prism, SoftMax Pro, PLA, and JMP. Familiar with electronic notebooks and documentation workflows. Basic statistical programming is a plus. * Ability to balance competing priorities and thrive in a dynamic, fast-paced environment * Excellent laboratory, critical thinking, scientific problem-solving, and organizational skills * Excellent oral and written communication skills * Motivated, detail-oriented, naturally curious individual with a creative approach to scientific problem solving and a burning desire to help patients with neurodegenerative diseases. Salary Range: $96,000.00 to $134,000.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at ****************************************** This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. This position is required to be based in San Francisco, CA. Key Accountabilities/Core Job Responsibilities * Legal Compliance: Advise on employment laws applicable to Denali's California, Utah, and Switzerland offices and remote employees, including wage and hour regulations, anti-discrimination laws, and leave policies. * Policy Development: Draft, review, and update employee handbooks, workplace policies, and SOPs to ensure compliance and alignment with Denali culture. * Employee Relations: Partner with HR to provide guidance on complex employee relations issues, investigations, and performance management. * Litigation and Risk Management: Manage and oversee the resolution of employment-related disputes and coordinate responses to agencies. * Hiring and Onboarding: Support the development of compliant hiring practices, offer letters, and onboarding materials. * Training: Develop and deliver training programs for managers and employees on employment law topics, including performance feedback, leave policies, and workplace conduct. * Immigration Oversight: Oversee and support immigration matters, manage relationships with immigration counsel, and ensure timely and efficient outcomes. * Cross-Functional Support: Collaborate with teams on employment-related aspects of business strategies, including international expansion and benefits. Support the establishment of a strong, integrated culture across sites. Skills/Qualifications: * J.D. degree from an accredited law school. * Active California bar membership in good standing. * 7+ years of relevant work experience. * Expertise in U.S. federal, state, and local employment laws and regulations required; familiarity with Swiss employment law preferred. * Proven experience advising on employee relations, policy development, and compliance. * Experience in the biotech, life sciences, or technology sectors preferred. * Strong project management skills and ability to prioritize in a fast-paced environment. * Exceptional verbal and written communication skills, the ability to communicate with tact and diplomacy, and a deep, abiding sense of compassion and integrity. * Growth mindset, with a willingness to learn new things, expand outside boundaries, and broaden areas of expertise. No task is too big or too small. * Ability to thrive efficiently in a fast-paced environment, managing a heavy workload at times and adapting quickly to change. * Excellent judgment, complemented by an awareness of when to seek guidance and collaboration. * Willingness to courageously and clearly identify risks and seek solutions. * A proven record of building trust and credibility through consistent and reliable partnerships with business functions. Salary Range: $225,000.00 to $272,000.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at ****************************************** This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. Denali is seeking a highly skilled and experienced Senior Manager of Market Planning, reporting to the Executive Director of Global Insights & Operations, to support the commercialization efforts of Denali's first launch and pipeline assets with market insights and strategic support. You will be responsible for driving market analysis (including market research and competitive intelligence), strategic planning, and forecasting to support the successful development and commercialization of our pipeline products. As part of an emerging biopharma company, the ideal candidate will thrive in a resource efficient, nimble, and fast-paced environment, foster a collaborative, patient-focused culture, and be able to flex across priorities. Key Accountabilities/Core Job Responsibilities: * Market Analysis & Competitive Intelligence: * Conduct in-depth market research and analysis of market trends, competitive landscapes, customer needs, and industry developments to identify opportunities and risks for programs across our portfolio. * Lead and maintain up-to-date competitive intelligence and ensure timely socialization to relevant teams. * Strategic Planning: * Synthesize insights and collaborate with cross-functional teams, including R&D, commercial, sales, access, and regulatory teams to develop and refine short- and long-term market strategies and tactical plans. * New Product Planning: Serve as commercial strategic partner for pre-commercial assets, supporting multiple development teams with market landscape and commercial insights to help develop robust CDPs, TPPs, and opportunity assessments. * Forecasting and Modeling: * Build and maintain robust market models and forecasts for US and ex-US geographies to guide product development decisions, investment planning, and commercial launch strategies. Collaborate with supply chain to ensure appropriate launch supply readiness. * Build short-term forecast model pre-launch; Post-launch, analyze market data and historical sales trends to predict near-future product demand and provide insights to support sales, marketing, and supply chain decisions based on these forecasts; * Product Positioning: Work closely with marketing, sales, medical affairs, clinical and development teams to define value propositions, market segmentation, and product positioning strategies. * Stakeholder Engagement: * Present findings and recommendations to senior leadership and key stakeholders to drive informed decision-making and align strategic priorities. * Create and deliver high quality reports and presentations to communicate insights and recommendations effectively. * Market Entry Planning: Support the development of launch plans, pricing strategies, and go-to-market initiatives for new product introductions. * Data-Driven Insights: Leverage advanced analytics, external market data, and internal resources to generate actionable insights that enhance competitive advantage. Qualifications/Skills: * Highly motivated self-starter with strong analytical and strategic capabilities, outstanding communication and interpersonal skills * BA or BS in Health Sciences or related discipline, PhD/MD/MBA is a plus * At or near 5 years of experience in the pharmaceutical industry or healthcare consulting, with relevant experience in data analysis, decision support, market research, forecasting and commercial planning. Prior experience in a market planning, strategy marketing or pipeline marketing function is a plus * Strong aptitude and interest in science, drug development process and commercialization pathways, particularly in the biopharma space * Proficiency in market analysis tools, market research techniques, forecasting methodologies, and competitive intelligence. * Previous experience in neurology and/or rare disease with understanding of unmet medical needs, standard of care and market dynamics is a plus * Exceptional analytical, problem-solving skills, and good business judgment, with the ability to synthesize complex data into actionable strategies. * Proven track record of cross-functional collaboration and stakeholder engagement. * Ability to prioritize and flex in a fast-paced growth environment * Strategic agility, comfort and open-mindedness in the face of uncertainty, and willingness to right-size approach as needed * Curiosity, strong work ethic and a sense of humor * A strong passion for developing therapies to help patients Salary Range: $0.00 to $0.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at ****************************************** This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. Key Accountabilities/Core Job Responsibilities: Provide clinical, scientific, and strategic leadership for translational and early clinical projects, including leading early clinical-stage project teams Responsible for the design, execution, analysis, interpretation, and presentation of clinical and translational studies Plan, organize, and direct the activities of clinical trials, including development of clinical protocols and amendments, investigator brochures, and clinical study reports Provide medical monitoring support, including evaluation of safety, pharmacology, and efficacy of ongoing and completed studies Establish and implement exploratory pharmacodynamic, diagnostic, and biomarker plans in conjunction with partners in Clinical Pharmacology and Translational Sciences Interact with external thought leaders, key disease community stakeholders, including advisory boards, to support clinical and translational development Establishes, leads, and manages relationships with key development partners as applicable. Represent team and organization strategy to decision/governance meetings. Participate in the development and execution of strategies for new product development and lifecycle growth, including regulatory and investigator interactions Prepare literature reviews, external presentations, and publications as appropriate Qualifications/Skills: MD or MD/PhD physician-scientist with strong understanding of translational disease biology and a track record of designing and executing innovative early-stage trials 2+ years clinical development experience in industry. Extensive experience in drug development or clinical trials in other settings (e.g. academia, government) may be considered. A strong track record in team leadership, development of clinical-regulatory strategies, and/or industry-academic collaborations Training in adult or pediatric neurology or research experience in neuroscience preferred but not required Interest and flexibility to work across multiple indications with high unmet need and ability to develop expertise in new disease areas quickly Excellent presentation skills and ability to communicate effectively with external partners and with preclinical, biomarker, regulatory, operations, biostatistical and computational collaborators Salary Range: $252,000.00 to $300,000.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at ****************************************** This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Our mission is to develop therapies that empower the immune system to combat neurodegeneration and our team is focused on developing treatments for some of the most challenging diseases facing our society. By harnessing advancements in genetics, immunology and neuroscience, we are pioneering the development of potential therapies to counteract the devastating progression of neurodegeneration. We are supported in this mission by experienced and accomplished scientists and clinicians, a novel portfolio of programs, leading healthcare investors, and pharma company partners, who share in our commitment to bettering the lives of patients and realizing a world where we make brain disorders history. As a Senior Research Associate, you will be part of an Analytical Development Team and will work closely with Analytical team members and other members of Process Sciences. Communication and dedication are key aspects required in this role. You will have the opportunity to work collaboratively with cross-functional members across multi-discipline departments and multi-levels including cell culture, upstream, purification, discovery, pre-clinical, and research. Alector is seeking a candidate with hands-on experience in protein characterization and protein formulation stability. The successful candidate should have a strong scientific foundation and be experienced with mass spectrometry operations and methodologies as well as be familiar with various chromatography methods such as Affinity, SEC, IEX, HIC, RP-HPLC and other analytical techniques such as ELISA, CE-IEF and CE-SDS. During your first year, your goals will include:Perform analytical method developments for various leading drug candidates Carry out formulation stability studies for new molecules from research to critical reagents and supporting IND filings Conduct mass spectrometry experiments of early and late-stage, research biomolecules, internal discovery efforts and phase appropriate IND/BLA filings We'd love to hear from you if you have:A BS in scientific discipline e.g. chemistry, biochemistry, with 5+ years of related experience or an MS in scientific discipline e.g. chemistry, biochemistry, with 2-4 years of related experience1-2 years of hand on experience in mass spectrometry. Plus for Orbitrap and sample preparation for MSHands-on experience in many laboratory analytical techniques including ELISA, CE-IEF, CE-SDS.Hands-on experience in chromatography development work including RP, HIC, IEX, SEC and SEC-MALS.Demonstrated ability to design, execute and analyze experiments independently.Able to follow protocols and test methods.A team player, willing to work together, and share knowledge and work accomplishments.Strong and effective interpersonal skills with managers, peers, and cross-functional groups.Thrive and foster a culture of open communication and trust Strong organizational skills and strong attention to detail Ability to prioritize work to support drug development and meet deadlines and timeframes.Effective work ethic and dedication to completing challenging projects.Strong problem-solving capabilities.Authored or co-author various technical documents, including Comparability Studies, GLP Studies, and Qualification Studies is a plus.Prepared and presented scientific findings at internal/departmental meetings $40 - $55 an hour Hourly ranges will be determined by the candidate's level, qualifications, skill set, and experience #LI-CH1 #LI-Onsite At Alector, our vision is bold, people are our priority, and our values are at the core of everything we do. Our dynamic and flexible environment encourages our teams to experiment, take ownership of decisions, and question convention to solve complex problems. We value shared wins, perseverance, and a growth mindset, which drives us forward, together. Among the things you'll discover at Alector from your very first day are our committed and driven colleagues, a bold company vision, and new, modern offices designed to inspire innovation and collaboration in South San Francisco, right at the heart of Biotech Bay. Our benefits are thoughtfully designed around Alectorians and their loved ones and include flexible hybrid work options, competitive compensation, and comprehensive and unique benefits that enhance your health and well-being. Come join us! We believe that hard-working teams include people from a wide variety of backgrounds and experiences who can challenge each other's assumptions with fresh perspectives and bring creative ideas to the table. We are committed to building an open, diverse, and inclusive environment for all employees. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, sexual orientation, age, marital status, veteran status, or disability status, or any other characteristics protected under applicable federal, state, or local laws. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, perform essential job functions, and receive other benefits and privileges of employment. Please contact us to request accommodation. Review our Privacy Policy

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. This position is responsible for developing efficient, robust and scalable purification processes to support our large molecule pipeline. Key Accountabilities/Core Job Responsibilities: Design and execute lab-scale chromatography and filtration studies to inform and support large scale process decisions Maintain existing workflows to provide purification support for cell line and cell culture development activities Develop purification processes to support early and late-stage clinical production Execute methods for in-process testing using ELISA, HPLC, UV and SDS-PAGE based analytics Transfer purification processes to clinical manufacturing sites and support ongoing manufacturing campaigns as needed Author process descriptions, development reports, tech transfer documents and relevant IND sections Work closely with discovery groups and project teams to transfer process/molecule knowledge into development Qualifications/Skills: PhD in Biology, Biochemistry, Chemical Engineering, or related scientific discipline with 0-5 years of purification process development experience in academia/industry or BS or MS with 5+ years of industry experience Experience developing protein purification processes to support early or late-stage clinical production Experience with late-stage process characterization and validation is a plus Proven track record of representing bioprocess functions in cross-functional teams and working effectively with CMOs Knowledge of process virology, including working with contract labs to plan and execute viral clearance studies is desired Broad experience in protein characterization, multivariate experimentation and analytical techniques Expertise in AKTA protein purification, tangential and normal flow filter sizing Excellent critical thinking, scientific problem-solving and communication skills Salary Range: $125,000.00 to $157,000.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at ****************************************** This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. This role involves leading a dedicated team within the Development Sciences organization, collaborating with Discovery Sciences, Translational Medicine, and Regulatory teams, and providing scientific and strategic input to advance promising drug candidates to clinical trials. The ideal candidate will possess a strong background in pharmacokinetics, drug disposition, biodistribution, and translational pharmacology, with a proven track record in advancing molecules through CTA/IND milestones to first-in-human clinical trials. Key Accountabilities/Core Job Responsibilities: Deliver on key Project Team objectives and advance portfolio of blood-brain-barrier penetrant TV biotherapeutics by providing scientific contributions in areas of pharmacokinetics, drug disposition and biodistribution, and translational pharmacology/pharmacodynamics Lead and manage a group within the Development Sciences organization, providing strategic project-focused vision and oversight to advance drug candidates from Discovery through CTA/IND-enabling studies into Early Clinical Development. Participate on Project Teams as a subject matter expert contributing to the optimization and selection of lead clinical candidates, and support Group members serving in this role Design nonclinical PK/PD studies to answer translational questions in support of project deliverables and first-in-human dose predictions; oversee TK analysis for non-GLP and GLP toxicology studies. Lead Project Teams or Pharmacology Technical Teams in the CTA/IND-enabling stage. Serve on the Development Sciences Leadership Team; set Function and Organizational goals. Establish and maintain productive relationships with key partners within the organization, including Discovery Sciences, Bioanalytical Sciences, Safety Assessment, Clinical Pharmacology, Translational Medicine, and Regulatory to advance projects to key decisions and achieve development milestones. Analyze, interpret, summarize and communicate data to internal project teams, senior management, global health authorities, and strategic partners. Author and review nonclinical and clinical sections of regulatory filings. Lead direct report(s) through annual goal setting, growth planning, adherence to company policies, maintain training compliance and provide ongoing feedback on growth, development and areas of improvement. Qualifications/Skills: A highly motivated individual with a PhD in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology/Toxicology, Engineering, or related field and 10+ years of relevant work experience to include any postdoctoral work; must also have demonstrated experience as a people manager / mentor / coach Established expertise in biotherapeutic drug disposition and pharmacokinetics, with experience identifying clinical candidates and successfully advancing molecules through CTA/IND milestones to FIH clinical trials. Proven track record evaluating drug properties that may impact PK, investigating PK/PD relationships, and identifying relevant bioanalytical methods (ligand binding assays, mass spectrometry, or other methodologies) to assess biotherapeutic drug disposition. Well developed leadership skills in managing groups and developing scientific talent. Experience serving and/or leading cross-functional Project Teams, with success contributing to data driven decision-making, outlining strategies to enable drug development, and working collaboratively. Excellent critical thinking and scientific skills, and a demonstrated ability to analyze, interpret, and clearly communicate complex results. Excellent oral and written communication and presentation skills. Salary Range: $213,000.00 to $255,667.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at ****************************************** This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. Key Accountabilities/Core Job Responsibilities: Distribution Management: Build and maintain strong partnerships with 3PLs, specialty distributors, specialty pharmacies, and customers. Oversee the performance of distribution partners to ensure efficient and compliant operations including quarterly business reviews (QBRs). Develop strategies to support medicine launches, ensure supply continuity, and address distribution challenges. Data Flow, SAP integration & Reporting: Serve as the Denali commercial representative on its SAP implementation team. Lead the integration and optimization of channel operations workflows within the SAP ERP system, ensuring alignment with commercial, accounting, and gross-to-net processes. Manage inventory, sales, and chargeback data flows to ensure timely and accurate information sharing across stakeholders and systems. Collaborate with and manage outsourced vendors to ensure high-quality data integration, aggregation, analytics, and reporting services. Provide data-driven insights to inform decision-making and support market access strategies. Contract Administration: Administer any contract related payments with 3PLs, specialty distributors, specialty pharmacies and customers. Ensure accuracy and classification of contract-related payments for partners and help ensure data structures and data flows provide for government price reporting accuracy and compliance. Ensure documentation and secure database for all contract related contracts, SOP's, and payments and that customers receive accurate contract pricing. Operational Oversight: Monitor performance metrics and contractual compliance for distribution partners and outsourced vendors. Drive continuous improvement initiatives to optimize the distribution model, contract administration process and enhance efficiencies. Ensure adherence to regulatory requirements and industry standards. Cross-Functional Collaboration: Partner with internal teams, including supply chain, government price reporting lead, commercial, regulatory, and finance, to align distribution activities with organizational goals and help ensure compliance. Serve as a key point of contact for resolving distribution-related issues and fostering teamwork across functions. Contribute as appropriate with technical operations and the supply chain team on all topics that may impact product packaging. Act as a key contact for external auditors, responding to inquiries and data requests, and assisting in resolution of discrepancies. Prepare and maintain audit-ready documentation to support SOX compliance and other regulatory requirements. Qualifications Bachelor's degree in business, supply chain, or related field (MBA or advanced degree preferred). 7+ years of experience in channel operations, distribution, and supply chain within the biopharma or healthcare industry. Experience managing relationships with 3PLs, specialty distributors, and specialty pharmacies. Strong knowledge of data management, including inventory, sales, and chargeback processes. Experience with administering distribution and customer related contracts. Experience with ERP systems including SAP Familiarity with rare disease markets and the unique challenges of patients with rare diseases. Exceptional project management, analytical, and problem-solving skills. Excellent communication and interpersonal skills with a collaborative mindset. Critical Success Factors Flexibility and Agility: Ability to thrive in a fast-paced, efficient environment and manage competing priorities. Strategic and Tactical Balance: Capable of shaping long-term strategies while executing operational details effectively. Team Player: Willingness to collaborate across functions and contribute to a positive, solution-oriented culture. Proactive Mindset: Anticipates challenges, seeks innovative solutions, and takes initiative to improve processes. This is a unique opportunity to play a key role in the success of Denali which is dedicated to making a difference in the lives of patients. Salary Range: $183,000.00 to $232,333.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at ****************************************** This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. This position will primarily be at the bench to independently conceive, initiate, and direct protein production and related technology development efforts, in alignment with the goals of the Biotherapeutic Discovery organization and responsible for leading the production of large molecule biotherapeutics from milligram to gram scale, including development of robust and scalable purification processes and fit-for-purpose analytics that support the identification and characterization of novel therapeutics Key Accountabilities/Core Job Responsibilities: * Develop and troubleshoot protein expression and purification processes for large molecule biotherapeutics. * Evaluate and establish technologies to enhance and/or advance protein production and characterization, including high-throughput approaches, in support of Discovery projects, platforms, and pathways. * Develop and perform protein purification, biophysical and biochemical characterizations. In this capacity, support and meet timelines for production of a wide variety of proteins, including antibodies, enzymes, Fc-fusions, bioconjugated proteins, and protein complexes. * Analyze proteins using standard methods (including HPLC, SEC-MALS, CE-SDS, DLS, DSF, MCE and others). * Coordinate activities and work collaboratively with colleagues across Discovery and Development to meet timelines and to help advance programs. * Think creatively about ways to integrate novel protein modalities with Denali's BBB-crossing technologies. * Actively contribute to project teams and work effectively across functional teams to help advance programs to development. Qualifications/Skills: * PhD in Biochemistry or related scientific discipline with >5 years of experience in biotech/biopharma industry; or M.Sc with ≥8; or or B.Sc. ≥12 years of relevant experience, respectively. * Extensive knowledge and hands-on experience in the purification and analytical characterization of challenging proteins, complexes and fusion proteins. * Demonstrated and documented experience in producing and assessing the purity and activity of complex proteins such as engineered antibodies, Fc-fusions and/or bioconjugated therapeutics. * Extensive programming experience of automated liquid handlers and/or protein purification platforms (FPLC/HPLC/robotics). * Excellent oral, presentation and written communication skills are required. * Ability to work in a highly dynamic and fast paced environment to contribute to multiple projects. * Self-motivated with excellent record keeping and written and verbal communication skills. * Creative thinker with a strong sense of responsibility and a desire to collaborate in an exciting and fast-paced research environment. Salary Range: $129,000.00 to $181,000.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at ****************************************** This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.